Lung Function of Preterm Children Parsed by a Polygenic Risk Score for Adult COPD.
Publisher DOI
PubMed ID
38320054
Abstract
Lung Function of Preterm Children by COPD PRSPolygenic risk score (PRS) for FEV1 and FVC was calculated in children born prematurely. COPD risk score was strongly associated with FEV1 (-0.05 z score/decile, P=6.5 × 10-9) and FEV1/FVC (-0.07 z score/decile, P=4.4 × 10-11) but not FVC. Children at highest risk had lower lung function by these measures and higher rates of obstructive bronchitis.
Date Issued
2023-03
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Nissen, Gyde | |
Hinsenbrock, Svenja | |
Rausch, Tanja K | |
Stichtenoth, Guido | |
Ricklefs, Isabell | |
Weckmann, Markus | |
Franke, Andre | |
Herting, Egbert | |
König, Inke R | |
Rabe, Klaus F | |
Göpel, Wolfgang |
Additional Credits
Journal
NEJM Evidence
Publisher
NEJM Group
ISSN
2766-5526
Access(Rights)
restricted