The Concise Guide to PHARMACOLOGY 2025/26: Enzymes.

DOI
Publisher DOI
PubMed ID
41461578
Abstract
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of the more detailed information and links available at the www.guidetopharmacology.org website, the printed guide serves as a permanent, citable, point-in-time record, that remains stable despite ongoing updates to the online database. The full contents of this publication can be found at https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70234. The Concise Guides provide expert-curated recommendations of 'Gold Standard' selective pharmacological tools, available either commercially or as donations, which enable the identification of individual drug targets or families of drug targets. While the Concise Guide offers a more streamlined overview, more comprehensive information, including detailed pharmacological profiles and links to multiple online databases, is available through the Guide to Pharmacology website. The 2025/26 edition of the Concise Guide is based on material current as of mid-2025, and supersedes all previous editions, including the 2023/24 Guide, and earlier Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), and as such provides official IUPHAR classification and nomenclature for human drug targets, where applicable. Enzymes are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and transporters. Each section includes nomenclature guidance, concise summaries, information of the best available pharmacological tools, key references, and suggestions for further reading.
Date Issued
2025-12
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Alexander, Stephen P H
Gibb, Alasdair J
Kelly, Eamonn
Mathie, Alistair A
Peach, Chloe J
Veale, Emma L
Armstrong, Jane F
Faccenda, Elena
Harding, Simon D
Southan, Christopher
Davies, Jamie A
Annett, Stephanie
Boison, Detlev
Burns, Kathryn Elisa
Dessauer, Carmen
Helsby, Nuala Ann
Izzo, Angelo A
Ostrom, Rennolds
Pagano, Ester
Papapetropoulos, Andreas
Pyne, Nigel J
Pyne, Susan
Robson, Tracy
Seifert, Roland
Stasch, Johannes-Peter
Szabo, Csaba
van der Stelt, Mario
van der Vliet, Albert
Watts, Val
Wong, Szu Shen
Journal
British Journal of Pharmacology
Publisher
Wiley
ISSN
1476-5381
0007-1188
Access(Rights)
open.access
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