TAP deficiency syndrome: chronic rhinosinusitis and conductive hearing loss
Publisher DOI
PubMed ID
18283480
Abstract
Nose-ear-throat manifestations of immunodeficiency disorders represent a diagnostic challenge for clinicians as these diseases often constitute the initial sign for connective disorders or autoimmune disease. The history of chronic rhinosinusitis and conductive hearing loss is often non specific. Therefore attention to an HLA class I deficiency must be considered if the disease has not been diagnosed on routine examination. One of the syndromes is due to a defective TAP complex, the peptide transporter complex associated with antigen presentation. Herein, we report two sisters with TAP-deficiency. The treatment of choice for TAP-deficient patients is conservative.
Date Issued
2008
Publication Type
Article
Language(s)
en
Author(s)
Carter, Rachel | |
Williams, Anthony P | |
Gadola, Stephan D |
Journal
European archives of oto-rhino-laryngology
Publisher
Springer-Verlag
ISSN
0937-4477
ISBN
18283480
Access(Rights)
open.access