Histidine-derived N-heterocyclic Carbenes in Metal Peptide Conjugates for Abiotic Catalysis.
Publisher DOI
PubMed ID
42104890
Abstract
Histidinium (Hum), a N,N'-dimethylated variant of histidine, serves as a non-canonical amino acid that provides an N-heterocyclic carbene (NHC) binding site for metal coordination. This amino acid therefore allows for combining peptides and proteins with NHC metal complexes, one of the most prolific scaffolds of homogeneous catalysis of the recent past. Here, we review our efforts in combining these two areas by constructing chemically synthesized tetrapeptide NHC rhodium conjugates for hydrosilylation and larger peptide metal systems obtained from solid phase peptide synthesis for abiotic iridium-catalysed hydrogenation of ketones.
Date Issued
2026-04-29
Publication Type
Article
Subject(s)
Subjects
Carbene
•
Catalysis
Language(s)
en
Journal
CHIMIA
Publisher
Swiss Chemical Society
ISSN
0009-4293
Access(Rights)
open.access