Targeting the endocannabinoid-eicosanoid axis to treat pain: Promise and pitfalls.
Publisher DOI
PubMed ID
41544615
Abstract
In this issue of Cell Chemical Biology, Tufail et al.1 demonstrate that the peripheral diacylglycerol lipase α/β inhibitor A1480LS exerts potent anti-inflammatory and analgesic effects by blocking 2-arachidonoylglycerol synthesis and reducing arachidonate-derived eicosanoid production. However, potential risks from altered protein kinase C signaling due to elevated diacylglycerols warrant further evaluation in future therapeutic applications.
Date Issued
2026-01-15
Publication Type
Article
Language(s)
en
Journal
Cell Chemical Biology
Publisher
Cell Press
ISSN
2451-9448
2451-9456
Access(Rights)
restricted