Regulation of pulmonary plasma cell responses during secondary infection with influenza virus.
Publisher DOI
PubMed ID
38661717
Abstract
During secondary infection with influenza virus, plasma cells (PCs) develop within the lung, providing a local source of antibodies. However, the site and mechanisms that regulate this process are poorly defined. Here, we show that while circulating memory B cells entered the lung during rechallenge and were activated within inducible bronchus-associated lymphoid tissues (iBALTs), resident memory B (BRM) cells responded earlier, and their activation occurred in a different niche: directly near infected alveoli. This process required NK cells but was largely independent of CD4 and CD8 T cells. Innate stimuli induced by virus-like particles containing ssRNA triggered BRM cell differentiation in the absence of cognate antigen, suggesting a low threshold of activation. In contrast, expansion of PCs in iBALTs took longer to develop and was critically dependent on CD4 T cells. Our work demonstrates that spatially distinct mechanisms evolved to support pulmonary secondary PC responses, and it reveals a specialized function for BRM cells as guardians of the alveoli.
Date Issued
2024-07-01
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
MacLean, Andrew J | |
Bonifacio, Joao P P L | |
Oram, Sophia L | |
Arnon, Tal I |
Journal
The Journal of experimental medicine
Publisher
Rockefeller Univ. Press
ISSN
1540-9538
Access(Rights)
open.access