Modern Solutions for Ancient Pathogens: Direct Pathogen Sequencing for Diagnosis of Lepromatous Leprosy and Cerebral Coenurosis.

DOI
Publisher DOI
PubMed ID
36119959
Abstract
Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pathogen DNA sequencing provides flexible solutions to diagnosis of difficult pathogens in diverse contexts.
Date Issued
2022-09
Publication Type
Article
Subject(s)
Subjects
Taenia coenurosis leprosy mycobacteria whole genome sequencing
Language(s)
en
Author(s)
Young, Bernadette C
Bush, Stephen J
Lipworth, Sam
George, Sophie
Dingle, Kate E
Sanderson, Nick
Brankin, Alice
Walker, Timothy
Sharma, Srilakshmi
Leong, James
Plaha, Puneet
Hofer, Monika
Chiodini, Peter
Furrer, Lavinia
Crook, Derrick
Brent, Andrew
Additional Credits
Journal
Open Forum Infectious Diseases
Publisher
Oxford University Press
ISSN
2328-8957
Access(Rights)
open.access
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