Real-world Pattern-of-Care Analysis of Cutaneous Lymphomas Radiotherapy Among EORTC Members.
Publisher DOI
PubMed ID
39549760
Abstract
Purpose
We aim to determine the current treatment patterns and recommendations among physicians for cutaneous lymphomas and to identify the types of skin lymphomas for which existing radiation regimens need improvement.Materials/methods
A questionnaire from the European Organisation for Research and Treatment of Cancer (EORTC) was distributed to all members of the Cutaneous Lymphoma Tumour Group and radiation oncology scintific council. This online survey included 13 questions regarding treatment practices for patients with cutaneous lymphoma. The survey was conducted from August 21 to December 18, 2023. Frequency distributions and subgroup comparisons were calculated and analyzed.Results
We collected 51 completed questionnaires from investigators from 19 countries specializing in cutaneous lymphoma treatment. Radiation doses varied significantly (range, 4-60 Gy). Based on the histologic entity, up to one-third of the investigators delivered hypofractionated regimens (range, 14% - 35%). Reduced-dose radiotherapy was considered by 27% to 63% of investigators. Meanwhile, 18 (35%) investigators considered adapting the radiation dose to the response to immunochemotherapy when treating primary cutaneous diffuse large B-cell lymphomal-leg type. Regarding total skin electron beam therapy, 91% of centres delivered reduced-dose regimens, and 18% of investigators applied ultra-hypofractionated protocols.Conclusion
Radiotherapy of cutaneous lymphoma patients is highly heterogeneous among EORTC centres. Development of evidence-based recommendations for radiotherapy dose, fractionation, and technique for cutaneous lymphomas is required for optimization and standardization of treatment.
We aim to determine the current treatment patterns and recommendations among physicians for cutaneous lymphomas and to identify the types of skin lymphomas for which existing radiation regimens need improvement.Materials/methods
A questionnaire from the European Organisation for Research and Treatment of Cancer (EORTC) was distributed to all members of the Cutaneous Lymphoma Tumour Group and radiation oncology scintific council. This online survey included 13 questions regarding treatment practices for patients with cutaneous lymphoma. The survey was conducted from August 21 to December 18, 2023. Frequency distributions and subgroup comparisons were calculated and analyzed.Results
We collected 51 completed questionnaires from investigators from 19 countries specializing in cutaneous lymphoma treatment. Radiation doses varied significantly (range, 4-60 Gy). Based on the histologic entity, up to one-third of the investigators delivered hypofractionated regimens (range, 14% - 35%). Reduced-dose radiotherapy was considered by 27% to 63% of investigators. Meanwhile, 18 (35%) investigators considered adapting the radiation dose to the response to immunochemotherapy when treating primary cutaneous diffuse large B-cell lymphomal-leg type. Regarding total skin electron beam therapy, 91% of centres delivered reduced-dose regimens, and 18% of investigators applied ultra-hypofractionated protocols.Conclusion
Radiotherapy of cutaneous lymphoma patients is highly heterogeneous among EORTC centres. Development of evidence-based recommendations for radiotherapy dose, fractionation, and technique for cutaneous lymphomas is required for optimization and standardization of treatment.
Date Issued
2025-03-15
Publication Type
Article
Subjects
Sézary syndrome
•
anaplastic large cell lymphoma
•
cutaneous B cell lymphoma
•
cutaneous T cell lymphoma
•
diffuse large B cell lymphoma
•
follicular lymphoma
•
hypofractionation
•
low dose
•
marginal zone lymphoma
•
mycosis fungoides
•
overtreatment
Language(s)
en
Author(s)
Elsayad, Khaled | |
Guenova, Emmanuella | |
Fournier, Beatrice | |
Fernandes, Carolina | |
Clementel, Enrico | |
Papadavid, Evangelia | |
Barry, Marie Beylot | |
Pavlotsky, Felix | |
Specht, Lena | |
Levis, Mario | |
Morris, Stephen | |
Campbell, Belinda | |
Nicolay, Jan P | |
Cowan, Richard | |
Assaf, Chalid | |
Ortiz-Romero, Pablo L | |
Kouloulias, Vassilis | |
de Masson, Adele | |
Dalle, Stephane | |
Clavère, Pierre | |
Schlaak, Max | |
Booken, Nina | |
Wobser, Marion | |
Mitteldorf, Christina | |
Aviv, Barzilai | |
Mareco, Virgínia | |
Gallardo, Fernando | |
Dummer, Reinhard | |
Gross, Markus | |
Ehret, Felix | |
Lancia, Andrea | |
Tomasik, Bartłomiej | |
Hawley, Lorna | |
Rermouchamps, Vincent | |
Ibrahim, Mona Abdel-Halim | |
Gawish, Ahmed | |
Abouegylah, Mohamed | |
Stuschke, Martin | |
Baten, Adinda | |
Eich, Hans Theodor |
Additional Credits
Journal
International Journal of Radiation Oncology - Biology - Physics
Publisher
Elsevier
ISSN
1879-355X
0360-3016
Access(Rights)
open.access