Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.
Options
BORIS DOI
Publisher DOI
PubMed ID
32224121
Description
Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.
Date of Publication
2020-05
Publication Type
Article
Subject(s)
Keyword(s)
Apicomplexa Bumped Kinase Inhibitor Calcium-dependent Protein Kinases Cryptosporidium Gatekeeper Neospora Sarcocystis Toxoplasma
Language(s)
en
Contributor(s)
Choi, Ryan | |
Hulverson, Matthew A | |
Huang, Wenlin | |
Vidadala, Rama S R | |
Whitman, Grant R | |
Barrett, Lynn K | |
Schaefer, Deborah A | |
Betzer, Dana P | |
Riggs, Michael W | |
Doggett, J Stone | |
Ortega-Mora, Luis Miguel | |
McCloskey, Molly C | |
Arnold, Samuel L M | |
Hackman, Robert C | |
Marsh, Kennan C | |
Lynch, James J | |
Freiberg, Gail M | |
Leroy, Bruce E | |
Kempf, Dale J | |
Choy, Robert K M | |
de Hostos, Eugenio L | |
Maly, Dustin J | |
Fan, Erkang | |
Ojo, Kayode K | |
Van Voorhis, Wesley C |
Additional Credits
Series
International journal for parasitology
Publisher
Elsevier
ISSN
1879-0135
Access(Rights)
restricted