Good Timing Matters: The Spatially Fractionated High Dose Rate Boost Should Come First.
Publisher DOI
PubMed ID
36497446
Abstract
Monoplanar microbeam irradiation (MBI) and pencilbeam irradiation (PBI) are two new concepts of high dose rate radiotherapy, combined with spatial dose fractionation at the micrometre range. In a small animal model, we have explored the concept of integrating MBI or PBI as a simultaneously integrated boost (SIB), either at the beginning or at the end of a conventional, low-dose rate schedule of 5x4 Gy broad beam (BB) whole brain radiotherapy (WBRT). MBI was administered as array of 50 µm wide, quasi-parallel microbeams. For PBI, the target was covered with an array of 50 µm × 50 µm pencilbeams. In both techniques, the centre-to-centre distance was 400 µm. To assure that the entire brain received a dose of at least 4 Gy in all irradiated animals, the peak doses were calculated based on the daily BB fraction to approximate the valley dose. The results of our study have shown that the sequence of the BB irradiation fractions and the microbeam SIB is important to limit the risk of acute adverse effects, including epileptic seizures and death. The microbeam SIB should be integrated early rather than late in the irradiation schedule.
Date Issued
2022-12-02
Publication Type
Article
Subject(s)
Subjects
brain tissue tolerance high dose rate radiotherapy microbeam irradiation (MBI) pencilbeam irradiation (PBI)
Language(s)
en
Author(s)
Schültke, Elisabeth | |
Jaekel, Felix | |
Bartzsch, Stefan | |
Bräuer-Krisch, Elke | |
Requardt, Herwig | |
Blattmann, Hans | |
Hildebrandt, Guido |
Additional Credits
Journal
Cancers
Publisher
MDPI AG
ISSN
2072-6694
Access(Rights)
open.access