Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping

Publisher DOI
PubMed ID
23045247
Abstract
Targeting of the HER2 protein in human breast cancer represents a major advance in oncology but relies on measurements of total HER2 protein and not HER2 signaling network activation. We used reverse-phase protein microarrays (RPMA) to measure total and phosphorylated HER2 in the context of HER family signaling to understand correlations between phosphorylated and total levels of HER2 and downstream signaling activity.
Date Issued
2012
Publication Type
Article
Language(s)
en
Author(s)
Wulfkuhle, Julia D
Berg, Daniela
Wolff, Claudia
Tran, Kai
Illi, Julie
Espina, Virginia
Pierobon, Mariaelena
Deng, Jianghong
DeMichele, Angela
Walch, Axel
Bronger, Holger
Becker, Ingrid
Waldhör, Christine
Höfler, Heinz
Esserman, Laura
Liotta, Lance A
Becker, Karl-Friedrich
Petricoin, Emanuel F
Additional Credits
Journal
Clinical cancer research
Publisher
American Association for Cancer Research
ISSN
1078-0432
Access(Rights)
metadata.only
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