Short- and long-term outcome and predictors in an international cohort of patients with neuro COVID-19.
Publisher DOI
PubMed ID
35194889
Abstract
BACKGROUND
Despite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short and long-term outcome of the disease.
METHODS
This is a cohort study enrolling adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the EAN NEuro-covid ReGistrY. The outcome at discharge was measured using the modified Rankin Scale (mRS) and defined as: "stable/improved" if mRS score was equal or lower than pre-morbid score; "worse" if the score was higher than pre-morbid score. Status at 6 months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6 months.
RESULTS
From July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor/coma, stroke and ICU admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor/coma and ICU admission were associated with death. 262 were followed for 6 months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65/221 hospitalized patients (29.4%) and 10/32 non-hospitalized patients (24.4%) experienced persisting neurological symptoms/signs. 10/262 patients (3.8%) developed new neurological complaints during the 6 months of follow-up.
CONCLUSIONS
Neuro-COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection.
Despite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short and long-term outcome of the disease.
METHODS
This is a cohort study enrolling adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the EAN NEuro-covid ReGistrY. The outcome at discharge was measured using the modified Rankin Scale (mRS) and defined as: "stable/improved" if mRS score was equal or lower than pre-morbid score; "worse" if the score was higher than pre-morbid score. Status at 6 months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6 months.
RESULTS
From July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor/coma, stroke and ICU admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor/coma and ICU admission were associated with death. 262 were followed for 6 months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65/221 hospitalized patients (29.4%) and 10/32 non-hospitalized patients (24.4%) experienced persisting neurological symptoms/signs. 10/262 patients (3.8%) developed new neurological complaints during the 6 months of follow-up.
CONCLUSIONS
Neuro-COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection.
Date Issued
2022-06
Publication Type
Article
Subject(s)
Subjects
COVID-19 SARS-CoV-2 neurological disorders outcome predictors
Language(s)
en
Author(s)
Beghi, Ettore | |
Helbok, Raimund | |
Oztturk, Serefnur | |
Karadas, Omer | |
Lisnic, Vitalie | |
Grosu, Oxana | |
Kovács, Tibor | |
Dobronyi, Levente | |
Bereczki, Daniel | |
Cotelli, Maria Sofia | |
Turla, Marinella | |
Davidescu, Eugenia Irene | |
Popescu, Bogdan Ovidiu | |
Valzania, Franco | |
Cavallieri, Franceso | |
Ulmer, Hanno | |
Maia, Luis F | |
Amodt, Anne Hege | |
Armon, Carmel | |
Brola, Waldemer | |
Gryb, Victoria | |
Riahi, Anis | |
Krehan, Ingomar | |
von Oertzen, Tim | |
Azab, Mohammed A | |
Crean, Michael | |
Lolich, Maria | |
Lima, Maria João | |
Sellner, Johann | |
Perneczky, Julian | |
Jenkins, Tom | |
Meoni, Sara | |
Bianchi, Elisa | |
Moro, Elena |
Additional Credits
Journal
European journal of neurology
Publisher
Wiley
ISSN
1468-1331
Access(Rights)
open.access