Bio-Inspired Micro- and Nano-Scale Surface Features Produced by Femtosecond Laser-Texturing Enhance TiZr-Implant Osseointegration.
Publisher DOI
PubMed ID
38857489
Abstract
Surface design plays a critical role in determining the integration of dental implants with bone tissue. Femtosecond laser-texturing has emerged as a breakthrough technology offering excellent uniformity and reproducibility in implant surface features. However, when compared to state-of-the-art sandblasted and acid-etched surfaces, laser-textured surface designs typically underperform in terms of osseointegration. This study investigated the capacity of a bio-inspired femtosecond laser-textured surface design to enhance osseointegration compared to state-of-the-art sandblasted & acid-etched surfaces. Laser-texturing facilitates the production of an organized trabeculae-like microarchitecture with superimposed nano-scale laser-induced periodic surface structures on both 2D and 3D samples of titanium-zirconium-alloy. Following a boiling treatment to modify the surface chemistry, improving wettability to a contact angle of 10°, laser-textured surfaces enhance fibrin network formation when in contact with human whole blood, comparable to state-of-the-art surfaces. In vitro experiments demonstrate that laser-textured surfaces significantly outperform state-of-the-art surfaces with a 2.5-fold higher level of mineralization by bone progenitor cells after 28 days of culture. Furthermore, in vivo evaluations reveal superior biomechanical integration of laser-textured surfaces after 28 days of implantation. Notably, during abiological pull-out tests, laser-textured surfaces exhibit comparable performance, suggesting that the observed enhanced osseointegration is primarily driven by the biological response to the surface. This article is protected by copyright. All rights reserved.
Date Issued
2024-09
Publication Type
Article
Subject(s)
Subjects
femtosecond laser implant osseointegration laser‐texturing mineralization
Language(s)
en
Author(s)
Lackington, William Arthur | |
Bellon, Benjamin | |
Guimond, Stefanie | |
Schweizer, Peter | |
Cancellieri, Claudia | |
Ambeza, Antoine | |
Chopard-Lallier, Anne-Lise | |
Armutlulu, Andac | |
Maeder, Xavier | |
Schmutz, Patrik | |
Rottmar, Markus |
Journal
Advanced healthcare materials
Publisher
Wiley
ISSN
2192-2659
Access(Rights)
open.access