A role for multiple estrogen receptors in immune regulation of common carp.
Publisher DOI
PubMed ID
27062969
Abstract
Estrogens are important for bi-directional neuroendocrine-immune interaction. They act via nuclear estrogen receptors (ERα and ERβ) and/or G-protein coupled receptor - GPR30. We found expression of ERα, ERβ and GPR30 in carp lymphoid tissues and head kidney monocytes/macrophages, neutrophils and lymphocytes. Interestingly, ERβ is also expressed in some head kidney lymphocytes but not in naive PBLs. Immune stimulation altered the cell type specific profile of expression of these receptors, which depends on both activation and maturation stage. This implies direct leukocyte responsiveness to estrogen stimulation and therefore in vitro effects of 17β-estradiol (E2) on reactive oxygen species (ROS) production in monocytes/macrophages were determined. Short-time incubation with E2 increased ROS production in PMA-stimulated cells. Results comply with mediation by GPR30, partially functioning via phosphoinositide 3-kinase activation. These results furthermore demonstrate that neuroendocrine-immune communication via estrogen receptors is evolutionary conserved.
Date Issued
2017-01
Publication Type
Article
Subject(s)
Subjects
17β-estradiol Carp Estrogen receptors GPR30 Immune response Monocyte/macrophage
Language(s)
en
Author(s)
Szwejser, Ewa | |
Maciuszek, Magdalena | |
Verburg-van Kemenade, B M Lidy | |
Chadzinska, Magdalena |
Additional Credits
Journal
Developmental and Comparative Immunology
Publisher
Elsevier
ISSN
0145-305X
Access(Rights)
restricted