Identification of ureteral stones at reduced radiation exposure: a pilot study comparing conventional versus digital low-dosage linear slot scanning (Lodox) radiography.
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BORIS DOI
Publisher DOI
PubMed ID
31165230
Description
PURPOSE
Digital low-dosage, linear slot scanning radiography (Lodox) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox as a diagnostic imaging modality in patients with ureterolithiasis.
METHODS
Conventional kidney-ureter-bladder (KUB) X-ray and Lodox were performed in 41 patients presenting with acute flank pain due to unilateral ureteral stone confirmed by computed tomography. KUB X-ray and Lodox images were then reviewed by four blinded readers (urology expert/resident, radiology expert/resident). Identification rates were compared using Pearson's Chi square test. The impact of different parameters on stone identification by Lodox was evaluated using logistic regression and generalized linear mixed models. Inter-reader agreement was tested using Cohen's kappa coefficient.
RESULTS
Median stone size was 5 mm (range 2-12), median stone density was 800 HU (range 200-1500). The identification rates of the urology expert were 68% for KUB X-ray and 90% for Lodox (p = 0.014), and for all four readers 61% for KUB X-ray and 62% for Lodox (p = 0.8). Radiation exposure for KUB X-ray and Lodox was 0.45 mSv (SD ± 0.64) and 0.027 mSv (SD ± 0.038), respectively. Multivariable analyses showed an association between stone identification by Lodox and stone size (p < 0.001), stone density (p = 0.005), lower body mass index (p = 0.005), and reader (p < 0.001).
CONCLUSIONS
The high identification rates and low radiation doses of Lodox make it a promising imaging modality for the diagnosis of ureteral stones. Further validation in larger cohorts, including performance evaluation for renal stones, is warranted.
TRIAL REGISTRATION
http://www.controlled-trails.com/ISRCTN12915426 .
Digital low-dosage, linear slot scanning radiography (Lodox) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox as a diagnostic imaging modality in patients with ureterolithiasis.
METHODS
Conventional kidney-ureter-bladder (KUB) X-ray and Lodox were performed in 41 patients presenting with acute flank pain due to unilateral ureteral stone confirmed by computed tomography. KUB X-ray and Lodox images were then reviewed by four blinded readers (urology expert/resident, radiology expert/resident). Identification rates were compared using Pearson's Chi square test. The impact of different parameters on stone identification by Lodox was evaluated using logistic regression and generalized linear mixed models. Inter-reader agreement was tested using Cohen's kappa coefficient.
RESULTS
Median stone size was 5 mm (range 2-12), median stone density was 800 HU (range 200-1500). The identification rates of the urology expert were 68% for KUB X-ray and 90% for Lodox (p = 0.014), and for all four readers 61% for KUB X-ray and 62% for Lodox (p = 0.8). Radiation exposure for KUB X-ray and Lodox was 0.45 mSv (SD ± 0.64) and 0.027 mSv (SD ± 0.038), respectively. Multivariable analyses showed an association between stone identification by Lodox and stone size (p < 0.001), stone density (p = 0.005), lower body mass index (p = 0.005), and reader (p < 0.001).
CONCLUSIONS
The high identification rates and low radiation doses of Lodox make it a promising imaging modality for the diagnosis of ureteral stones. Further validation in larger cohorts, including performance evaluation for renal stones, is warranted.
TRIAL REGISTRATION
http://www.controlled-trails.com/ISRCTN12915426 .
Date of Publication
2020-04
Publication Type
Article
Subject(s)
Keyword(s)
Imaging Lodox® Radiation exposure Urolithiasis
Language(s)
en
Contributor(s)
Fiechter, Stefanie | |
Geissbühler, Elio | |
Meierhans, Susan | |
Series
World journal of urology
Publisher
Springer-Verlag
ISSN
0724-4983
Access(Rights)
open.access