Seizure activity occurring in two dogs after S-ketamine-induction.
Publisher DOI
PubMed ID
24091232
Abstract
Two healthy dogs were anaesthetized to undergo elective orthopaedic procedures. After premedication with methadone and acepromazine, general anaesthesia was induced with midazolam and S-ketamine. Immediately after anaesthetic induction, seizures occurred in both dogs. In the first dog the syndrome was characterized by tonic and clonic motor activity, muscular hypertone, hypersalivation, urination, defecation and hyperthermia. In the second dog muscular twitches of the temporal and masseter regions were observed, followed by increased skeletal muscles tone, hypersalivation, spontaneous urination and increase in body temperature. Recoveries from anaesthesia were uneventful and no seizures were observed. Considering the temporal association between anaesthetic induction and occurrence of seizures, and the fact that other causative factors could not be identified, it is hypothesized that S-ketamine played a role in determining the convulsive phenomena observed in these patients. S-ketamine might carry the potential for inducing seizures in otherwise healthy dogs, despite the concomitant use of GABA-ergic drugs.
Date Issued
2013-10
Publication Type
Article
Subject(s)
Subjects
Hund
•
Krampfanfall
•
Narkose-Einleitung
•
Nebenwirkung
•
S-Ketamin
•
S-ketamine
•
adverse reaction
•
anaesthetic induction
•
dog
•
seizures
Language(s)
de
Additional Credits
Journal
Schweizer Archiv für Tierheilkunde
Publisher
Huber
ISSN
0036-7281
Access(Rights)
restricted