Alternative outcomes for the multiple breath washout in children with CF
Publisher DOI
PubMed ID
25578856
Abstract
BACKGROUND
The lung clearance index (LCI) measured by multiple-breath washout (MBW) has been proposed as an outcome for clinical trials; however, MBW is time consuming and LCI can be affected by breathing pattern. We aimed to evaluate moment ratios and abbreviated LCI in school-aged children with mild-to-moderate CF lung disease.
METHODS
Using existing data from three studies we assessed the sensitivity of moment ratios and abbreviated LCIs to (i) detect mild-to-moderate CF lung disease and (ii) detect treatment effects after 4weeks of hypertonic saline or dornase alfa inhalation. MBW was measured by respiratory mass spectrometry using 4% "sulphur hexafluoride as a tracer gas.
RESULTS
Compared to the traditional LCI, moment ratios and abbreviated LCIs were similarly sensitive to detect CF lung disease. Moment ratios consistently demonstrated treatment effects, whereas abbreviated LCIs were less sensitive.
CONCLUSIONS
Both moment ratios and abbreviated LCI are suitable to differentiate health from disease. Sensitivity is decreased for abbreviated LCIs in interventional studies in mild CF lung disease.
The lung clearance index (LCI) measured by multiple-breath washout (MBW) has been proposed as an outcome for clinical trials; however, MBW is time consuming and LCI can be affected by breathing pattern. We aimed to evaluate moment ratios and abbreviated LCI in school-aged children with mild-to-moderate CF lung disease.
METHODS
Using existing data from three studies we assessed the sensitivity of moment ratios and abbreviated LCIs to (i) detect mild-to-moderate CF lung disease and (ii) detect treatment effects after 4weeks of hypertonic saline or dornase alfa inhalation. MBW was measured by respiratory mass spectrometry using 4% "sulphur hexafluoride as a tracer gas.
RESULTS
Compared to the traditional LCI, moment ratios and abbreviated LCIs were similarly sensitive to detect CF lung disease. Moment ratios consistently demonstrated treatment effects, whereas abbreviated LCIs were less sensitive.
CONCLUSIONS
Both moment ratios and abbreviated LCI are suitable to differentiate health from disease. Sensitivity is decreased for abbreviated LCIs in interventional studies in mild CF lung disease.
Date Issued
2015-01-08
Publication Type
Article
Subject(s)
Subjects
Clinical trials
•
Cystic fibrosis
•
Multiple breath washout
Language(s)
en
Author(s)
Stanojevic, Sanja | |
Jensen, Renee | |
Sundaralingam, Dasiga | |
Salazar, Juliana Giraldo | |
Amin, Reshma | |
Subbarao, Padmaja | |
Gustafsson, Per | |
Ratjen, Felix |
Journal
Journal of cystic fibrosis
Publisher
Elsevier
ISSN
1569-1993
Access(Rights)
restricted