Comparison of the binding and internalization properties of 12 DOTA-coupled and ¹¹¹In-labelled CCK2/gastrin receptor binding peptides: a collaborative project under COST Action BM0607

DOI
Publisher DOI
PubMed ID
21523391
Abstract
Specific overexpression of cholecystokinin 2 (CCK2)/gastrin receptors has been demonstrated in several tumours of neuroendocrine origin. In some of these cancer types, such as medullary thyroid cancer (MTC), a sensitive diagnostic modality is still unavailable and therapeutic options for inoperable lesions are needed. Peptide receptor radionuclide therapy (PRRT) may be a viable therapeutic strategy in the management of these patients. Several CCK2R-targeted radiopharmaceuticals have been described in recent years. As part of the European Union COST Action BM0607 we studied the in vitro and in vivo characteristics of 12 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated CCK2R binding peptides. In the present study, we analysed binding and internalization characteristics. Stability, biodistribution and imaging studies have been performed in parallel by other centres involved in the project.
Date Issued
2011
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Aloj, Luigi
Aurilio, Michela
Rinaldi, Valentina
D'ambrosio, Laura
Tesauro, Diego
Peitl, Petra Kolenc
Maina, Theodosia
Mansi, Rosalba
von Guggenberg, Elisabeth
Joosten, Lieke
Sosabowski, Jane K
Breeman, Wouter A P
De Blois, Erik
Koelewijn, Stuart
Melis, Marleen
de Jong, Marion
Additional Credits
Journal
European journal of nuclear medicine and molecular imaging
Publisher
Springer
ISSN
1619-7070
Access(Rights)
open.access
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