Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy
Publisher DOI
PubMed ID
30414049
Abstract
Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88) and specificity (82) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes.
Date Issued
2019
Publication Type
Article
Subject(s)
Subjects
Eeg John Cunningham virus encephalopathy Multiple sclerosis Natalizumab Pharmacovigilance Screening
Language(s)
en
Author(s)
Classen, G. | |
Classen, C. | |
Brandt, C. | |
Gold, R. |
Additional Credits
Journal
Journal of neurovirology
Publisher
Springer
ISSN
1538-2443
Access(Rights)
Unknown