Usefulness and Reliability of the Bispectral Index during Balanced Anesthesia for Neurovascular Surgery in New Zealand White Rabbits

DOI
Publisher DOI
Abstract
Few data about the electroencephalogram and its calculated indices, such as the bispectral index (BIS), have been reported in rabbits. We aimed to evaluate whether a clinically stable anesthesia was mirrored by consistent and stable BIS values and to investigate the effects of modified cerebral blood supply, due to bilateral carotid clamping and re-opening, on BIS values. We also investigated the effects of fentanyl, as an antinociceptive drug, on the BIS. Sixty-eight rabbits undergoing general anesthesia for surgical creation of carotid bifurcation aneurysms were enrolled. The BIS values were recorded at nine selected time points (TPs) during each procedure and before and after fentanyl administration. The BIS values over time were compared with two-way repeated-measures analysis of variance followed by Tukey test, while the Wilcoxon signed rank test was performed to compare values at clamping and re-opening of the carotids as well as before and after fentanyl administration. The BIS values were significantly lower during anesthesia than at the end of anesthesia and at tracheal extubation; no significant differences were found among other TPs. Adequate depth of anesthesia was mirrored by consistent BIS values among rabbits, and alteration of cerebral blood supply did not modify BIS values, except once. Following fentanyl, BIS values did not change in a clinically relevant way.
Date Issued
2023-02-14
Publication Type
Article
Subject(s)
Subjects
bispectral index
•
balanced anesthesia
•
neuromonitoring
•
neurosurgery
•
rabbits
•
fentanyl
•
carotid bifurcation
•
experimental anesthesia
Language(s)
en
Author(s)
Department for BioMedical Research, ESF
Boillat, Gwendoline
Department for BioMedical Research, ESF
Department for BioMedical Research, ESF
Additional Credits
Department for BioMedical Research, ESF
Journal
Brain Sciences
Publisher
MDPI
ISSN
2076-3425
Access(Rights)
open.access
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