Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population

DOI
Publisher DOI
PubMed ID
26683888
Abstract
BACKGROUND AND OBJECTIVES

Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown, and were therefore explored in this study.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

Urinary uromodulin excretion was measured using a validated ELISA in two population-based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age±SD, 45±17 years) who underwent renal ultrasonography and performed a 24-hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age, 53±11 years) with fresh spot morning urine samples. We calculated eGFRs using the CKD-Epidemiology Collaboration formula and by 24-hour creatinine clearance.

RESULTS

In both studies, positive associations were found between uromodulin and urinary sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin excretion (median, 41 [interquartile range, 29-57] mg/24 h) was positively associated with kidney length and volume and with creatinine excretion and urine volume. It was negatively associated with age and diabetes. Both spot uromodulin concentration and 24-hour uromodulin excretion were linearly and positively associated (multivariate analyses) with eGFR<90 ml/min per 1.73 m(2).

CONCLUSION

Age, creatinine excretion, diabetes, and urinary volume are independent clinical correlates of urinary uromodulin excretion. The associations of uromodulin excretion with markers of tubular functions and kidney dimensions suggest that it may reflect tubule activity in the general population.
Date Issued
2016-01-07
Publication Type
Article
Subject(s)
Subjects
electrolytes; glomerular filtration rate; humans; hypertension
•
renal; osmolality; potassium; renal insufficiency
•
chronic; renal tubular cells; sodium; uromodulin
Language(s)
en
Author(s)
Pruijm, Menno
Ponte, Belen
Paccaud, Fred
Guessous, Idris
Ehret, Georg
Pechère-Bertschi, Antoinette
Martin, Pierre-Yves
Youhanna, Sonia C
Nägele, Nadine
Vollenweider, Peter
Waeber, Gérard
Burnier, Michel
Devuyst, Olivier
Bochud, Murielle
Additional Credits
Journal
Clinical journal of the American Society of Nephrology
Publisher
American Society of Nephrology
ISSN
1555-9041
Access(Rights)
restricted
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