Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement.

DOI
Publisher DOI
PubMed ID
29943397
Abstract
BACKGROUND

Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce.

OBJECTIVE

To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years.

METHODS

Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses.

RESULTS

Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified.

CONCLUSIONS

Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
Date Issued
2018-09
Publication Type
Article
Subject(s)
Subjects
CARPE chronic hand eczema clinical improvement epidemiology follow-up quality of life semantic map analysis
Language(s)
en
Author(s)
Ballmer-Weber, Barbara K
Gräni, Nora
Spring, Philippe
Bircher, Andreas
Anliker, Mark
Sonntag, Anne-Katharina
Piletta, Pierre
Huber, Caroline
Diepgen, Thomas L
Apfelbacher, Christian
Naldi, Luigi
Additional Credits
Journal
Contact dermatitis
Publisher
Wiley-Blackwell
ISSN
0105-1873
Access(Rights)
restricted
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