The impact of the temporal sequence of cranial radiotherapy and platin-based chemotherapy on hearing impairment in pediatric and adolescent CNS and head-and-neck cancer patients: A report from the PanCareLIFE consortium.

DOI
Publisher DOI
PubMed ID
37715472
Abstract
The impact of the temporal sequence by which cranial radiotherapy (CRT) and platin-based chemotherapy (PCth) are administered on sensorineural hearing loss (SNHL) in pediatric and adolescent central nervous system (CNS) and head-and-neck (HN) cancer patients has not yet been studied in detail. We examined the ototoxic effects of sequentially applied CRT and PCth. This study included children and adolescents with CNS and HN tumors who participated in the multicountry PanCareLIFE (PCL) consortium. Audiological outcomes were compared between patients who received CRT prior to PCth and those who received it afterwards. The incidence, degree and posttreatment progression of SNHL, defined as Muenster classification grade ≥MS2b, were evaluated in 141 patients. One hundred and nineteen patients were included in a time-to-onset analysis. Eighty-eight patients received CRT prior to PCth (Group 1) and 53 patients received PCth before CRT (Group 2). Over a median follow-up time of 1.6 years, 72.7% of patients in Group 1 experienced SNHL ≥ MS2b compared to 33.9% in Group 2 (P < .01). A time-to-onset analysis was performed for 74 patients from Group 1 and 45 patients from Group 2. Median time to hearing loss (HL) ≥ MS2b was 1.2 years in Group 1 and 4.4 years in Group 2 (P < .01). Thus, audiological outcomes were better for patients who received CRT after PCth than before. This finding should be further evaluated and considered within clinical practice in order to minimize hearing loss in children and adolescents with CNS and HN tumors.
Date Issued
2024-01-15
Publication Type
Article
Subject(s)
Subjects
PanCareLIFE project cranial radiotherapy platin-based chemotherapy posttreatment hearing loss therapy sequence
Language(s)
en
Author(s)
Scobioala, Sergiu
Parfitt, Ross
Matulat, Peter
Byrne, Julianne
Langer, Thorsten
Troschel, Fabian M
Hesping, Amélie E
Clemens, Eva
Kaatsch, Peter
Grabow, Desiree
Kaiser, Melanie
Spix, Claudia
Kremer, Leontien C
Calaminus, Gabriele
Baust, Katja
Elsner, Susanne
Haupt, Riccardo
Garré, Maria-Luisa
Gruhn, Bernd
Kepak, Tomas
Kepakova, Katerina
Winther, Jeanette Falck
Kenborg, Line
Rechnitzer, Catherine
Hasle, Henrik
Kruseova, Jarmila
Luks, Ales
Lackner, Herwig
Bielack, Stefan
Beck, Jörn-Dirk
Jürgens, Heribert
van den Heuvel-Eibrink, Marry M
Zolk, Oliver
Eich, Hans Theodor
Am Zehnhoff-Dinnesen, Antoinette
Additional Credits
Journal
International journal of cancer
Publisher
Wiley
ISSN
1097-0215
Access(Rights)
open.access
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