Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein
Publisher DOI
PubMed ID
24060902
Abstract
The BH3-only protein Bim is a critical initiator of apoptosis in hematopoietic cells. Bim is upregulated in response to growth factor withdrawal and in vitro studies have implicated the transcription factor Foxo3a as a critical inducer. To test the importance of this regulation in vivo, we generated mice with mutated Foxo-binding sites within the Bim promoters (Bim(ΔFoxo/ΔFoxo)). Contrary to Bim-deficient mice, Bim(ΔFoxo/ΔFoxo) mice had a normal hematopoietic system. Moreover, cytokine-dependent haematopoietic cells from Bim(ΔFoxo/ΔFoxo) and wt mice died at similar rates. These results indicate that regulation of Bim by Foxo transcription factors is not critical for the killing of hematopoietic cells.
Date Issued
2013-09
Publication Type
Article
Subject(s)
Subjects
apoptosis
•
Bcl-2
•
BH3-only proteins
•
Bim
•
hematopoiesis
Language(s)
en
Author(s)
Herold, Marco J. | |
Rohrbeck, Leona | |
Lang, Mathias J. | |
Grumont, Raelene | |
Gerondakis, Steve | |
Tai, Lin | |
Bouillet, Philippe | |
Strasser, Andreas |
Additional Credits
Journal
EMBO REPORTS
Publisher
Nature
ISSN
1469-221X
Access(Rights)
open.access