Advantages and controversies of depot antipsychotics in the treatment of patients with schizophrenia
Chancen und Kontroversen von Depotantipsychotika in der Behandlung von Patienten mit Schizophrenie
Publisher DOI
PubMed ID
26597275
Abstract
BACKGROUND
The objective of this article is to give an overview of the advantages and disadvantages of the use of depot antipsychotics in the treatment of schizophrenia. The focus is on efficacy, tolerability, relapse prevention, patient compliance and satisfaction compared to oral administration forms.
MATERIAL AND METHODS
A literature search was conducted in medical databases. The results of meta-analyses, randomized controlled trials and systematic reviews from the years 1999-2014 were included.
RESULTS AND DISCUSSION
Depot antipsychotics ensure maintenance of constant blood levels and a continuous medication delivery. The efficacy and tolerability of depot antipsychotics are comparable to oral administration forms. Due to an improved medication compliance a reduction of relapse and hospitalization rates can be achieved. This is a key focus for improving outcomes and reducing costs in the treatment of schizophrenia.
The objective of this article is to give an overview of the advantages and disadvantages of the use of depot antipsychotics in the treatment of schizophrenia. The focus is on efficacy, tolerability, relapse prevention, patient compliance and satisfaction compared to oral administration forms.
MATERIAL AND METHODS
A literature search was conducted in medical databases. The results of meta-analyses, randomized controlled trials and systematic reviews from the years 1999-2014 were included.
RESULTS AND DISCUSSION
Depot antipsychotics ensure maintenance of constant blood levels and a continuous medication delivery. The efficacy and tolerability of depot antipsychotics are comparable to oral administration forms. Due to an improved medication compliance a reduction of relapse and hospitalization rates can be achieved. This is a key focus for improving outcomes and reducing costs in the treatment of schizophrenia.
Date Issued
2016
Publication Type
Article
Subject(s)
Subjects
Compliance
•
Health costs
•
Relapse
•
Schizophrenia
•
Tolerability
Language(s)
de
Journal
Nervenarzt
Publisher
Springer-Medizin-Verlag
ISSN
0028-2804
Access(Rights)
open.access