Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma.
Publisher DOI
PubMed ID
25981402
Abstract
PURPOSE
To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC).
METHODS
A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death.
RESULTS
Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026).
CONCLUSIONS
These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC).
METHODS
A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death.
RESULTS
Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026).
CONCLUSIONS
These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
Date Issued
2016
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Gakis, Georgios | |
Morgan, Todd M | |
Efstathiou, Jason A | |
Keegan, Kirk A | |
Mischinger, Johannes | |
Todenhoefer, Tilman | |
Schubert, Tina | |
Zaid, Harras B | |
Hrbacek, Jan | |
Ali-El-Dein, Bedeir | |
Clayman, Rebecca H | |
Galland, Sigolene | |
Olugbade, Kola | |
Rink, Michael | |
Fritsche, Hans-Martin | |
Burger, Maximilian | |
Chang, Sam S | |
Babjuk, Marko | |
Stenzl, Arnulf | |
Daneshmand, Siamak |
Additional Credits
Journal
World journal of urology
Publisher
Springer
ISSN
0724-4983
Access(Rights)
open.access