A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry
Publisher DOI
PubMed ID
14609231
Abstract
A novel synthesis of 2'-deoxypseudoisocytidine as well as of its phosphoramidite building block for oligonucleotide synthesis is presented. The synthesis is based on Heck-coupling between N-protected pseudoisocytosine and a silyl protected furanoid glycal. With this procedure the corresponding phosphoramidite building block is obtained in 5 steps and an overall yield of 28%.
Date Issued
2003
Publication Type
Article
Subject(s)
Subjects
analogs & derivatives
Biochemistry
chemical synthesis
chemistry
Deoxycytidine
Molecular Structure
oligonucleotide
phosphoramidite
silyl
Support
Biochemistry
chemical synthesis
chemistry
Deoxycytidine
Molecular Structure
oligonucleotide
phosphoramidite
silyl
Support
•
Non-U.S.Gov't
synthesis
synthesis
Language(s)
en
Additional Credits
Journal
Nucleosides, nucleotides & nucleic acids
Publisher
Taylor & Francis
ISSN
1525-7770
Access(Rights)
restricted