In vivo role of capsular polysaccharide in Mycoplasma mycoides.

DOI
Publisher DOI
PubMed ID
30541131
Abstract
Capsular polysaccharides have been confirmed to be an important virulence trait in many gram-positive and gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In the current study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. capri or an engineered mutant lacking the capsular polysaccharide, galactofuranose. Goats infected with the mutant strain showed only transient fever. In contrast, 5 of 8 goats infected with the parental strain reached end-point criteria after infection. These findings confirm that galactofuranose is a virulence factor in M. mycoides.
Date Issued
2019-04-19
Publication Type
Article
Subject(s)
Subjects
M. mycoides subsp. capri Mycoplasma mycoides CPS carbohydrate galactofuranose glycan vaccine virulence factor
Language(s)
en
Author(s)
Schieck, Elise
Liljander, Anne
Sacchini, Flavio
Lartigue, Carole
Blanchard, Alain
Vashee, Sanjay
Additional Credits
Journal
The journal of infectious diseases
Publisher
Oxford University Press
ISSN
1537-6613
Access(Rights)
open.access
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