Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters.
Publisher DOI
PubMed ID
31998104
Abstract
The sensitizing effect of capsaicin has been previously characterized using laser and contact heat evoked potentials (LEPs and CHEPs) by stimulating in the primary area of hyperalgesia. Interestingly, only CHEPs reveal changes consistent with notion of peripheral sensitization (i.e., reduced latencies). The aim of this study was to investigate contact heat stimulation parameters necessary to detect peripheral sensitization related to the topical application of capsaicin, and therefore significantly improve the current method of measuring peripheral sensitization via CHEPs. Rapid contact heat stimulation (70°C/s) was applied from three different baseline temperatures (35, 38.5, and 42°C) to a 52°C peak temperature, before and after the topical application of capsaicin on the hand dorsum. Increased pain ratings in the primary area of hyperalgesia were accompanied by reduced N2 latency. Changes in N2 latency were, however, only significant following stimulation from 35 and 38.5°C baseline temperatures. These findings suggest that earlier recruitment of capsaicin-sensitized afferents occurs between 35 and 42°C, as stimulations from 42°C baseline were unchanged by capsaicin. This is in line with reduced thresholds of type II A-delta mechanoheat (AMH) nociceptors following sensitization. Conventional CHEP stimulation, with a baseline temperature below 42°C, is well suited to objectively detect evidence of peripheral sensitization.
Date Issued
2019
Publication Type
Article
Subject(s)
Subjects
EEG capsaicin contact heat evoked potentials hyperalgesia type II A mechanoheat nociceptors
Language(s)
en
Author(s)
Linde, Lukas D | |
Haefeli, Jenny | |
Jutzeler, Catherine R | |
McDougall, Jessica | |
Curt, Armin | |
Kramer, John L K |
Additional Credits
Journal
Frontiers in human neuroscience
Publisher
Frontiers Research Foundation
ISSN
1662-5161
Access(Rights)
open.access