Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis.
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BORIS DOI
Date of Publication
June 8, 2021
Publication Type
Article
Division/Institute
Author
Nogueira, Raul G | |
Qureshi, Muhammed M | |
Abdalkader, Mohamad | |
Martins, Sheila Ouriques | |
Yamagami, Hiroshi | |
Qiu, Zhongming | |
Mansour, Ossama Yassin | |
Sathya, Anvitha | |
Czlonkowska, Anna | |
Tsivgoulis, Georgios | |
Aguiar de Sousa, Diana | |
Demeestere, Jelle | |
Mikulik, Robert | |
Vanacker, Peter | |
Siegler, James E | |
Kõrv, Janika | |
Biller, Jose | |
Liang, Conrad W | |
Sangha, Navdeep S | |
Zha, Alicia M | |
Czap, Alexandra L | |
Holmstedt, Christine Anne | |
Turan, Tanya N | |
Ntaios, George | |
Malhotra, Konark | |
Tayal, Ashis | |
Loochtan, Aaron | |
Ranta, Annamarei | |
Mistry, Eva A | |
Alexandrov, Anne W | |
Huang, David Y | |
Yaghi, Shadi | |
Raz, Eytan | |
Sheth, Sunil A | |
Mohammaden, Mahmoud H | |
Frankel, Michael | |
Bila Lamou, Eric Guemekane | |
Aref, Hany M | |
Elbassiouny, Ahmed | |
Hassan, Farouk | |
Menecie, Tarek | |
Mustafa, Wessam | |
Shokri, Hossam M | |
Roushdy, Tamer | |
Sarfo, Fred S | |
Alabi, Tolulope Oyetunde | |
Arabambi, Babawale | |
Nwazor, Ernest O | |
Sunmonu, Taofiki Ajao | |
Wahab, Kolawole | |
Yaria, Joseph | |
Mohammed, Haytham Hussein | |
Adebayo, Philip B | |
Riahi, Anis D | |
Ben Sassi, Samia | |
Gwaunza, Lenon | |
Ngwende, Gift Wilson | |
Sahakyan, David | |
Rahman, Aminur | |
Ai, Zhibing | |
Bai, Fanghui | |
Duan, Zhenhui | |
Hao, Yonggang | |
Huang, Wenguo | |
Li, Guangwen | |
Li, Wei | |
Liu, Ganzhe | |
Luo, Jun | |
Shang, Xianjin | |
Sui, Yi | |
Tian, Ling | |
Wen, Hongbin | |
Wu, Bo | |
Yan, Yuying | |
Yuan, Zhengzhou | |
Zhang, Hao | |
Zhang, Jun | |
Zhao, Wenlong | |
Zi, Wenjie | |
Leung, Thomas W | |
Chugh, Chandril | |
Huded, Vikram | |
Menon, Bindu | |
Pandian, Jeyaraj Durai | |
Sylaja, P N | |
Usman, Fritz Sumantri | |
Farhoudi, Mehdi | |
Hokmabadi, Elyar Sadeghi | |
Horev, Anat | |
Reznik, Anna | |
Hoffmann, Rotem Sivan | |
Ohara, Nobuyuki | |
Sakai, Nobuyuki | |
Watanabe, Daisuke | |
Yamamoto, Ryoo | |
Doijiri, Ryosuke | |
Tokuda, Naoki | |
Yamada, Takehiro | |
Terasaki, Tadashi | |
Yazawa, Yukako | |
Uwatoko, Takeshi | |
Dembo, Tomohisa | |
Shimizu, Hisao | |
Sugiura, Yuri | |
Miyashita, Fumio | |
Fukuda, Hiroki | |
Miyake, Kosuke | |
Shimbo, Junsuke | |
Sugimura, Yusuke | |
Yagita, Yoshiki | |
Takenobu, Yohei | |
Matsumaru, Yuji | |
Yamada, Satoshi | |
Kono, Ryuhei | |
Kanamaru, Takuya | |
Yamazaki, Hidekazu | |
Sakaguchi, Manabu | |
Todo, Kenichi | |
Yamamoto, Nobuaki | |
Sonoda, Kazutaka | |
Yoshida, Tomoko | |
Hashimoto, Hiroyuki | |
Nakahara, Ichiro | |
Kondybayeva, Aida | |
Faizullina, Kamila | |
Kamenova, Saltanat | |
Zhanuzakov, Murat | |
Baek, Jang-Hyun | |
Hwang, Yangha | |
Lee, Jin Soo | |
Lee, Si Baek | |
Moon, Jusun | |
Park, Hyungjong | |
Seo, Jung Hwa | |
Seo, Kwon-Duk | |
Sohn, Sung Il | |
Young, Chang Jun | |
Ahdab, Rechdi | |
Wan Zaidi, Wan Asyraf | |
Aziz, Zariah Abdul | |
Basri, Hamidon Bin | |
Chung, Law Wan | |
Ibrahim, Aznita Binti | |
Ibrahim, Khairul Azmi | |
Looi, Irene | |
Tan, Wee Yong | |
Yahya, Nafisah Wan | |
Groppa, Stanislav | |
Leahu, Pavel | |
Al Hashmi, Amal M | |
Imam, Yahia Zakaria | |
Akhtar, Naveed | |
Pineda-Franks, Maria Carissa | |
Co, Christian Oliver | |
Kandyba, Dmitriy | |
Alhazzani, Adel | |
Al-Jehani, Hosam | |
Tham, Carol Huilian | |
Mamauag, Marlie Jane | |
Venketasubramanian, Narayanaswamy | |
Chen, Chih-Hao | |
Tang, Sung-Chun | |
Churojana, Anchalee | |
Akil, Esref | |
Aykaç, Ozlem | |
Ozdemir, Atilla Ozcan | |
Giray, Semih | |
Hussain, Syed Irteza | |
John, Seby | |
Le Vu, Huynh | |
Tran, Anh Duc | |
Nguyen, Huy Hoang | |
Pham, Thong Nhu | |
Nguyen, Thang Huy | |
Nguyen, Trung Quoc | |
Gattringer, Thomas | |
Enzinger, Christian | |
Killer-Oberpfalzer, Monika | |
Bellante, Flavio | |
De Blauwe, Sofie | |
Vanhooren, Geert | |
De Raedt, Sylvie | |
Dusart, Anne | |
Lemmens, Robin | |
Ligot, Noemie | |
Rutgers, Matthieu Pierre | |
Yperzeele, Laetitia | |
Alexiev, Filip | |
Sakelarova, Teodora | |
Bedeković, Marina Roje | |
Budincevic, Hrvoje | |
Cindrić, Igor | |
Hucika, Zlatko | |
Ozretic, David | |
Saric, Majda Seferovic | |
Pfeifer, Frantiek | |
Karpowic, Igor | |
Cernik, David | |
Sramek, Martin | |
Skoda, Miroslav | |
Hlavacova, Helena | |
Klecka, Lukas | |
Koutny, Martin | |
Vaclavik, Daniel | |
Skoda, Ondrej | |
Fiksa, Jan | |
Hanelova, Katerina | |
Nevsimalova, Miroslava | |
Rezek, Robert | |
Prochazka, Petr | |
Krejstova, Gabriela | |
Neumann, Jiri | |
Vachova, Marta | |
Brzezanski, Henryk | |
Hlinovsky, David | |
Tenora, Dusan | |
Jura, Rene | |
Jurák, Lubomír | |
Novak, Jan | |
Novak, Ales | |
Topinka, Zdenek | |
Fibrich, Petr | |
Sobolova, Helena | |
Volny, Ondrej | |
Christensen, Hanne Krarup | |
Drenck, Nicolas | |
Iversen, Helle Klingenberg | |
Simonsen, Claus Z | |
Truelsen, Thomas Clement | |
Wienecke, Troels | |
Vibo, Riina | |
Gross-Paju, Katrin | |
Toomsoo, Toomas | |
Antsov, Katrin | |
Caparros, Francois | |
Cordonnier, Charlotte | |
Dan, Maria | |
Faucheux, Jean-Marc | |
Mechtouff, Laura | |
Eker, Omer | |
Lesaine, Emilie | |
Ondze, Basile | |
Peres, Roxane | |
Pico, Fernando | |
Piotin, Michel | |
Pop, Raoul | |
Rouanet, Francois | |
Gubeladze, Tatuli | |
Khinikadze, Mirza | |
Lobjanidze, Nino | |
Tsikaridze, Alexander | |
Nagel, Simon | |
Ringleb, Peter Arthur | |
Rosenkranz, Michael | |
Schmidt, Holger | |
Sedghi, Annahita | |
Siepmann, Timo | |
Szabo, Kristina | |
Thomalla, Götz | |
Palaiodimou, Lina | |
Sagris, Dimitrios | |
Kargiotis, Odysseas | |
Klivenyi, Peter | |
Szapary, Laszlo | |
Tarkanyi, Gabor | |
Adami, Alessandro | |
Bandini, Fabio | |
Calabresi, Paolo | |
Frisullo, Giovanni | |
Renieri, Leonardo | |
Sangalli, Davide | |
Pirson, Anne V | |
Uyttenboogaart, Maarten | |
van den Wijngaard, Ido | |
Kristoffersen, Espen Saxhaug | |
Brola, Waldemar | |
Fudala, Małgorzata | |
Horoch-Lyszczarek, Ewa | |
Karlinski, Michal | |
Kazmierski, Radoslaw | |
Kram, Pawel | |
Rogoziewicz, Marcin | |
Kaczorowski, Rafal | |
Luchowski, Piotr | |
Sienkiewicz-Jarosz, Halina | |
Sobolewski, Piotr | |
Fryze, Waldemar | |
Wisniewska, Anna | |
Wiszniewska, Malgorzata | |
Ferreira, Patricia | |
Ferreira, Paulo | |
Fonseca, Luisa | |
Marto, João Pedro | |
Pinho E Melo, Teresa | |
Nunes, Ana Paiva | |
Rodrigues, Miguel | |
Cruz, Vítor Tedim | |
Falup-Pecurariu, Cristian | |
Krastev, Georgi | |
Mako, Miroslav | |
Alonso de Leciñana, María | |
Arenillas, Juan F | |
Ayo-Martin, Oscar | |
Culebras, Antonio Cruz | |
Tejedor, Exuperio Diez | |
Montaner, Joan | |
Pérez-Sánchez, Soledad | |
Tola Arribas, Miguel Angel | |
Vasquez, Alejandro Rodriguez | |
Mazya, Michael | |
Bernava, Gianmarco | |
Brehm, Alex | |
Machi, Paolo | |
Michel, Patrik L | |
Psychogios, Marios-Nikos | |
Strambo, Davide | |
Banerjee, Soma | |
Krishnan, Kailash | |
Kwan, Joseph | |
Butt, Asif | |
Catanese, Luciana | |
Demchuk, Andrew | |
Field, Thalia | |
Haynes, Jennifer | |
Hill, Michael D | |
Khosravani, Houman | |
Mackey, Ariane | |
Pikula, Aleksandra | |
Saposnik, Gustavo | |
Scott, Courtney Anne | |
Shoamanesh, Ashkan | |
Shuaib, Ashfaq | |
Yip, Samuel | |
Barboza, Miguel A | |
Barrientos, Jose Domingo | |
Portillo Rivera, Ligia Ibeth | |
Gongora-Rivera, Fernando | |
Novarro-Escudero, Nelson | |
Blanco, Anmylene | |
Abraham, Michael | |
Alsbrook, Diana | |
Altschul, Dorothea | |
Alvarado-Ortiz, Anthony J | |
Bach, Ivo | |
Badruddin, Aamir | |
Barazangi, Nobl | |
Brereton, Charmaine | |
Castonguay, Alicia | |
Chaturvedi, Seemant | |
Chaudhry, Saqib A | |
Choe, Hana | |
Choi, Jae H | |
Dharmadhikari, Sushrut | |
Desai, Kinjal | |
Devlin, Thomas G | |
Doss, Vinodh T | |
Edgell, Randall | |
Etherton, Mark | |
Farooqui, Mudassir | |
Frei, Don | |
Gandhi, Dheeraj | |
Grigoryan, Mikayel | |
Gupta, Rishi | |
Hassan, Ameer E | |
Helenius, Johanna | |
Kaliaev, Artem | |
Kaushal, Ritesh | |
Khandelwal, Priyank | |
Khawaja, Ayaz M | |
Khoury, Naim N | |
Kim, Benny S | |
Kleindorfer, Dawn O | |
Koyfman, Feliks | |
Lee, Vivien H | |
Leung, Lester Y | |
Linares, Guillermo | |
Linfante, Italo | |
Lutsep, Helmi L | |
Macdougall, Lisa | |
Male, Shailesh | |
Malik, Amer | |
Masoud, Hesham | |
McDermott, Molly | |
Mehta, Brijesh P | |
Min, Jiangyong | |
Mittal, Manoj | |
Morris, Jane G | |
Multani, Sumeet S | |
Nahab, Fadi | |
Nalleballe, Krishna | |
Nguyen, Claude B | |
Novakovic-White, Roberta | |
Ortega-Gutierrez, Santiago | |
Rahangdale, Rahul H | |
Ramakrishnan, Pankajavalli | |
Romero, Jose Rafael | |
Rost, Natalia | |
Rothstein, Aaron | |
Ruland, Sean | |
Shah, Ruchir | |
Sharma, Malveeka | |
Silver, Brian | |
Simmons, Marc | |
Singh, Abhishek | |
Starosciak, Amy K | |
Strasser, Sheryl L | |
Szeder, Viktor | |
Teleb, Mohamed | |
Tsai, Jenny P | |
Voetsch, Barbara | |
Balaguera, Oscar | |
Pujol Lereis, Virginia A | |
Luraschi, Adriana | |
Almeida, Marcele Schettini | |
Cardoso, Fabricio Buchdid | |
Conforto, Adriana | |
De Deus Silva, Leonardo | |
Giacomini, Luidia Varrone | |
Lima, Fabricio Oliveira | |
Longo, Alexandre L | |
Magalhães, Pedro Sc | |
Martins, Rodrigo Targa | |
Mont'alverne, Francisco | |
Mora Cuervo, Daissy Liliana | |
Rebello, Leticia Costa | |
Valler, Lenise | |
Zetola, Viviane Flumignan | |
Lavados, Pablo M | |
Navia, Victor | |
Olavarría, Verónica V | |
Almeida Toro, Juan Manuel | |
Ricardo Amaya, Pablo Felipe | |
Bayona, Hernan | |
Corredor-Quintero, Angel Basilio | |
Rivera Ordonez, Carlos Eduardo | |
Mantilla Barbosa, Diana Katherine | |
Lara, Osvaldo | |
Patiño, Mauricio R | |
Diaz Escobar, Luis Fernando | |
Dejesus Melgarejo Farina, Donoband Edson | |
Villamayor, Analia Cardozo | |
Zelaya Zarza, Adolfo Javier | |
Barrientos Iman, Danny Moises | |
Kadota, Liliana Rodriguez | |
Campbell, Bruce | |
Hankey, Graeme J | |
Hair, Casey | |
Kleinig, Timothy | |
Ma, Alice | |
Martins, Rodrigo Tomazini | |
Sahathevan, Ramesh | |
Thijs, Vincent | |
Salazar, Daniel | |
Yuan-Hao Wu, Teddy | |
Haussen, Diogo C | |
Liebeskind, David | |
Yavagal, Dileep | |
Jovin, Tudor G | |
Zaidat, Osama O | |
Nguyen, Thanh N |
Subject(s)
Series
Neurology
ISSN or ISBN (if monograph)
1526-632X
Publisher
American Academy of Neurology
Language
English
Publisher DOI
PubMed ID
33766997
Description
OBJECTIVE
The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods.
METHODS
We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases.
RESULTS
There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p<0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95%CI, -13.8 to -12.7, p<0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95%CI, -13.7 to -10.3, p=0.001). Recovery of stroke hospitalization volume (9.5%, 95%CI 9.2-9.8, p<0.0001) was noted over the two later (May, June) versus the two earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.3% (1,722/52,026) of all stroke admissions.
CONCLUSIONS
The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.
The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods.
METHODS
We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases.
RESULTS
There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p<0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95%CI, -13.8 to -12.7, p<0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95%CI, -13.7 to -10.3, p=0.001). Recovery of stroke hospitalization volume (9.5%, 95%CI 9.2-9.8, p<0.0001) was noted over the two later (May, June) versus the two earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.3% (1,722/52,026) of all stroke admissions.
CONCLUSIONS
The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| WNL.0000000000011885.full.pdf | Adobe PDF | 4.03 MB | publisher | accepted |