Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus
Publisher DOI
PubMed ID
18166599
Abstract
Polymyositis and interstitial lung diseases, predominantly nonspecific interstitial pneumonia (NSIP), are known to be frequent in antisynthetase syndrome, where anti-aminoacyl-tRNA synthetase antibodies are often identified. An unusual case of acute respiratory distress syndrome, secondary to such proven NSIP of cellular type with predominant CD8 lymphocytes, is described herein. The patient described in the present case study initially had a poor recovery with high dose of steroids, but this was followed by a good improvement after the prescription of tacrolimus and a low dose of prednisone. A precise diagnosis in similar circumstances may be life-saving, allowing the successful application of new immunosuppressants.
Date Issued
2008
Publication Type
Article
Language(s)
en
Author(s)
Journal
European respiratory journal
Publisher
European Respiratory Society
ISSN
0903-1936
ISBN
18166599
Access(Rights)
metadata.only