"Don't add fuel to the fire"- Hyperhemolysis Syndrome in a pregnant woman with compound Sickle cell disease/ß0-thalassemia - Case report and review of the literature
Publisher DOI
PubMed ID
37839398
Abstract
Hyperhemolysis Syndrome (HHS) is a rare and severe post-transfusion complication characterized by the destruction of both recipient and donor red blood cells (RBC). The underlying mechanism of HHS is not fully understood and proper management can be difficult. Furthermore, there are few reports regarding HHS in pregnancy. We report on the development and management of HHS in a pregnant woman with known compound Sickle cell disease/ß-0-thalassemia after transfusion of not fully compatible packed red blood cells (PRBC). We aim to raise awareness on this diagnostically challenging and life-threatening type of hemolysis with this report, and to stress the need to consider the diagnosis of HHS in SCD patients with progressive anemia despite PRBC administration.
Date Issued
2024
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Sanchez, Sergio | |
Henny, Christine | |
Crottet, Sofia Lejon |
Journal
Acta haematologica
Publisher
Karger
ISSN
0001-5792
Access(Rights)
open.access