Targeting the posterior subthalamic area for essential tremor: proposal for MRI-based anatomical landmarks.
Publisher DOI
PubMed ID
30497206
Abstract
OBJECTIVEDeep brain stimulation (DBS) of the posterior subthalamic area (PSA) is an alternative to thalamic DBS for the treatment of essential tremor (ET). The dentato-rubro-thalamic tract (DRTT) has recently been proposed as the anatomical substrate underlying effective stimulation. For clinical purposes, depiction of the DRTT mainly depends on diffusion tensor imaging (DTI)-based tractography, which has some drawbacks. The objective of this study was to present an accurate targeting strategy for DBS of the PSA based on anatomical landmarks visible on MRI and to evaluate clinical effectiveness.METHODSThe authors performed a retrospective cohort study of a prospective series of 11 ET patients undergoing bilateral DBS of the PSA. The subthalamic nucleus and red nucleus served as anatomical landmarks to define the target point within the adjacent PSA on 3-T T2-weighted MRI. Stimulating contact (SC) positions with reference to the midcommissural point were analyzed and projected onto the stereotactic atlas of Morel. Postoperative outcome assessment after 6 and 12 months was based on change in Tremor Rating Scale (TRS) scores.RESULTSActual target position corresponded to the intended target based on anatomical landmarks depicted on MRI. The total TRS score was reduced (improved) from 47.2 ± 15.7 to 21.3 ± 10.7 (p < 0.001). No severe complication occurred. The mean SC position projected onto the PSA at the margin of the cerebellothalamic fascicle and the zona incerta.CONCLUSIONSTargeting of the PSA based on anatomical landmarks representable on MRI is reliable and leads to accurate lead placement as well as good long-term clinical outcome.
Date Issued
2018-10-12
Publication Type
Article
Subject(s)
Subjects
AP = anteroposterior DBS DBS = deep brain stimulation DRTT = dentato-rubro-thalamic tract DTI = diffusion tensor imaging ET = essential tremor LAT = lateral MCP = midcommissural point MER = microelectrode recording PSA = posterior subthalamic area ROI = region of interest RaprL = prelemniscal radiation SC = stimulating contact STN = subthalamic nucleus TRS = Tremor Rating Scale VERT = vertical Vim = ventral intermediate nucleus ZI = zona incerta essential tremor fct = cerebellothalamic fascicle functional neurosurgery posterior subthalamic area targeting
Language(s)
en
Author(s)
Rossi, Frédéric | |
Journal
Journal of neurosurgery
Publisher
American Association of Neurological Surgeons
ISSN
0022-3085
Access(Rights)
restricted