L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
Publisher DOI
PubMed ID
17529983
Abstract
T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin-negative CCR7- effector and memory CD8+ T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4+ and CD8+ T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.
Date Issued
2007
Publication Type
Article
Language(s)
en
Author(s)
Guarda, Greta | |
Soriano, Silvia F | |
Huang, Alex Y | |
Polley, Rosalind | |
Martín-Fontecha, Alfonso | |
Germain, Ronald N | |
Lanzavecchia, Antonio | |
Sallusto, Federica |
Additional Credits
Journal
Nature immunology
Publisher
Nature Publishing Group
ISSN
1529-2908
ISBN
17529983
Access(Rights)
Unknown