Apoptosis regulation by autophagy gene 5
Publisher DOI
PubMed ID
17644402
Abstract
Autophagy is a cellular process, in which cellular proteins and cytoplasmic organelles are degraded. It reflects the response of a cell to stress or starvation with the primary goal of cell survival. On the other hand, if the autophagic activity is too high, cell death happens, suggesting that this process requires a tight control. Autophagic cell death has often been observed under conditions, in which apoptosis is blocked. Recent studies suggest that autophagy may promote apoptosis and that Bcl-2 cannot block only apoptosis, but also autophagy and autophagic cell death. Here, we discuss recent findings regarding the interrelations between autophagy and apoptosis. In particular, we would like to draw the attention of the readers to Atg5, which exhibits, like Bcl-2, a dual function by modulating both autophagy and apoptosis.
Date Issued
2007
Publication Type
Article
Language(s)
en
Additional Credits
Journal
Critical reviews in oncology, hematology
Publisher
Elsevier
ISSN
1040-8428
ISBN
17644402
Access(Rights)
metadata.only