[Pathophysiology of autoinflammatory dermatoses].
Pathophysiologie der autoinflammatorischen Dermatosen
Publisher DOI
PubMed ID
32333042
Abstract
Autoinflammation leads to inflammation that mostly occurs without any clinically obvious reason. It can be so severe that organ damage with relevant tissue damage occurs. Inflammasomes are the drivers of autoinflammation. Although IL‑1 beta and the inflammasomes as its critical regulators are very important in autoinflammation, not all patients respond to inhibition of this signalling pathway. Several autoinflammatory diseases were associated with mutations in proteasome-immunoproteasome components. Autoinflammatory diseases caused by highly relevant genetic variants are mostly hereditary. Usually in childhood but not always. The coming years will show whether inflammatory dermatoses will be increasingly treated with suppression of the innate immune system in addition to inhibition of adaptive immunity.
Date Issued
2020-05
Publication Type
Article
Subject(s)
Subjects
Autoinflammation Inflammasome Interleukin Monogenic autoinflammatory diseases Proteasome
Language(s)
de
Author(s)
Navarini, A A |
Additional Credits
Journal
Hautarzt
Publisher
Springer-Medizin-Verlag
ISSN
0017-8470
Access(Rights)
open.access