Accumulation of saturated intramyocellular lipid is associated with insulin resistance.
Publisher DOI
PubMed ID
31048405
Abstract
Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and to insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglyceride in biopsy samples, and hence the composition of specifically IMCL is unknown in these states. H magnetic resonance spectroscopy can overcome this, and we used a recently validated method to compare the compositional saturation index (CH:CH ratio) and concentration independent of composition (CH) of IMCL in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (n=14) and healthy controls (n=41). The IMCL CH:CH ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls, but was similar in athletes and controls. IMCL CH:CH was dependent on IMCL concentration in the controls, and after adjusting the composition index for quantity (CH:CH) was able to distinguish lipodystrophics from athletes. This CH:CH marker had a stronger relationship with insulin resistance than IMCL concentration alone, and was inversely related to VO The association of insulin resistance with accumulation of saturated IMCL is consistent with (a) a potential pathogenic role for saturated fat, and (b) the reported benefits of exercise and diet in insulin resistant states.
Date Issued
2019-07
Publication Type
Article
Subject(s)
Subjects
Insulin resistance Intramyocellular lipid composition Lipodystrophies Muscle NMR Triglycerides in vivo magnetic resonance spectroscopy
Language(s)
en
Author(s)
Savage, David B | |
Watson, Laura | |
Carr, Katie | |
Adams, Claire | |
Brage, Soren | |
Chatterjee, Krishna K | |
Hodson, Leanne | |
Kemp, Graham J | |
Sleigh, Alison |
Additional Credits
Journal
Journal of lipid research
Publisher
American Society for Biochemistry and Molecular Biology ASBMB
ISSN
0022-2275
Access(Rights)
open.access