Cholesteatoma triggering squamous cell carcinoma: case report and literature review of a rare tumor
Publisher DOI
PubMed ID
19563937
Abstract
BACKGROUND: The aim of this study was to report a case of squamous cell carcinoma of the petrous part of the temporal bone associated with a long history of secondary acquired cholesteatoma in a 71-year-old man. PATIENTS AND METHODS: We present the case of a 71-year-old man diagnosed with secondary acquired cholesteatoma in 1950. Treatments consisted of repetitive surgery owing to several relapses. In 2004, he presented with progressive fetid otorrhea. Clinical and computed tomography findings were indicative for relapsing cholesteatoma and a subtotal petrosectomy was performed. RESULTS: Histologic work-up demonstrated a moderately differentiated squamous cell carcinoma. The staging revealed stadium pT3 cN0 cM0. Postoperative treatment consisted of local radiation therapy with intensity-modulated beam geometry with a total of 64.2 Gy in 30 fractions using a simultaneous integrated boost. CONCLUSION: Middle ear carcinoma can arise from acquired cholesteatoma. The pathogenesis of squamous cell carcinoma associated with cholesteatoma has not been elucidated satisfactorily. Due to the complex anatomic features, intensity-modulated radiation therapy is the technique of choice for postoperative radiotherapy.
Date Issued
2009
Publication Type
Article
Language(s)
en
Author(s)
Ciernik, I Frank | |
Hartmann, Matthias | |
Schuknecht, Bernhard | |
Lütolf, Urs M | |
Huber, Alexander M |
Additional Credits
Journal
American journal of otolaryngology
Publisher
Elsevier
ISSN
0196-0709
Access(Rights)
metadata.only