Publication:
Compressive strength of elderly vertebrae is reduced by disc degeneration and additional flexion

cris.virtual.author-orcid0000-0002-4712-7047
cris.virtualsource.author-orcid09c1f812-a6cc-44d4-8cd8-fc5edb32adf2
cris.virtualsource.author-orcid234a3daf-a8ed-4ae1-b405-824e4b17295c
cris.virtualsource.author-orcid8e8a2467-96b0-4987-8997-57604a4b0630
dc.contributor.authorMaquer, Ghislain Bernard
dc.contributor.authorSchwiedrzik, Johann Jakob
dc.contributor.authorHuber, Gerd
dc.contributor.authorMorlock, Michael M.
dc.contributor.authorZysset, Philippe
dc.date.accessioned2024-10-23T17:19:21Z
dc.date.available2024-10-23T17:19:21Z
dc.date.issued2015-02
dc.description.abstractComputer tomography (CT)-based finite element (FE) models assess vertebral strength better than dual energy X-ray absorptiometry. Osteoporotic vertebrae are usually loaded via degenerated intervertebral discs (IVD) and potentially at higher risk under forward bending, but the influences of the IVD and loading conditions are generally overlooked. Accordingly, magnetic resonance imaging was performed on 14 lumbar discs to generate FE models for the healthiest and most degenerated specimens. Compression, torsion, bending, flexion and extension conducted experimentally were used to calibrate both models. They were combined with CT-based FE models of 12 lumbar vertebral bodies to evaluate the effect of disc degeneration compared to a loading via endplates embedded in a stiff resin, the usual experimental paradigm. Compression and lifting were simulated, load and damage pattern were evaluated at failure. Adding flexion to the compression (lifting) and higher disc degeneration reduces the failure load (8–14%, 5–7%) and increases damage in the vertebrae. Under both loading scenarios, decreasing the disc height slightly increases the failure load; embedding and degenerated IVD provides respectively the highest and lowest failure load. Embedded vertebrae are more brittle, but failure loads induced via IVDs correlate highly with vertebral strength. In conclusion, osteoporotic vertebrae with degenerated IVDs are consistently weaker—especially under lifting, but clinical assessment of their strength is possible via FE analysis without extensive disc modelling, by extrapolating measures from the embedded situation.
dc.description.numberOfPages13
dc.description.sponsorshipInstitut für chirurgische Technologien und Biomechanik (ISTB)
dc.identifier.doi10.7892/boris.61659
dc.identifier.publisherDOI10.1016/j.jmbbm.2014.10.016
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/128309
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of the mechanical behavior of biomedical materials
dc.relation.issn1751-6161
dc.relation.organizationDCD5A442BCD5E17DE0405C82790C4DE2
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.subject.ddc600 - Technology::620 - Engineering
dc.titleCompressive strength of elderly vertebrae is reduced by disc degeneration and additional flexion
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
dspace.file.typetext
oaire.citation.endPage66
oaire.citation.startPage54
oaire.citation.volume42
oairecerif.author.affiliationInstitut für chirurgische Technologien und Biomechanik (ISTB)
oairecerif.author.affiliationInstitut für chirurgische Technologien und Biomechanik (ISTB)
oairecerif.author.affiliationInstitut für chirurgische Technologien und Biomechanik (ISTB)
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.description.ispublishedpub
unibe.eprints.legacyId61659
unibe.journal.abbrevTitleJ MECH BEHAV BIOMED
unibe.refereedTRUE
unibe.subtype.articlejournal

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