Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response.
Publisher DOI
PubMed ID
37215983
Abstract
Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence play an important role in the regulation of the cell's fate. ROS can cause irreversible damage to DNA and proteins resulting in cell death. Therefore, finely tuned regulatory mechanisms exist in evolutionarily diverse organisms that are aimed at the neutralization of ROS and its consequences with respect to cellular damage. The SET domain-containing lysine methyltransferase Set7/9 (KMT7, SETD7, SET7, SET9) post-translationally modifies several histones and non-histone proteins via monomethylation of the target lysines in a sequence-specific manner. In cellulo, the Set7/9-directed covalent modification of its substrates affects gene expression, cell cycle, energy metabolism, apoptosis, ROS, and DNA damage response. However, the in vivo role of Set7/9 remains enigmatic. In this review, we summarize the currently available information regarding the role of methyltransferase Set7/9 in the regulation of ROS-inducible molecular cascades in response to oxidative stress. We also highlight the in vivo importance of Set7/9 in ROS-related diseases.
Date Issued
2023
Publication Type
Article
Subject(s)
Subjects
ROS metabolism Set7/9 chromatin diabetes myocardial ischemic injury nephropathy oxidative stress p53
Language(s)
en
Author(s)
Daks, Alexandra | |
Shuvalov, Oleg | |
Fedorova, Olga | |
Parfenyev, Sergey | |
Barlev, Nickolai A |
Additional Credits
Journal
International journal of biological sciences
ISSN
1449-2288
Access(Rights)
Unknown