Impact of Proportionality of Secondary Tricuspid Regurgitation on Outcomes After Tricuspid Transcatheter Edge-to-Edge Repair.
Publisher DOI
PubMed ID
41884946
Abstract
Background
The impact of proportionality to heart valve regurgitation has been widely investigated in mitral regurgitation, helping to better characterize the best candidates for therapies. However, it has never been studied in tricuspid regurgitation (TR). The aim of the present study is to investigate the impact of the proportionality of TR on outcomes.Methods
Patients undergoing tricuspid transcatheter edge-to-edge repair were selected from the TRIVALVE registry (International Multisite Transcatheter Tricuspid Valve Therapies Registry). Patients were divided according to the ratio between effective regurgitant orifice area (EROA) and right ventricular (RV) end diastolic diameter (RVEDD) into tertiles: patients with low EROA/RVEDD (RV, dominant); intermediate EROA/RVEDD (right ventricle and TR, RV-TR, codominant), and high EROA/RVEDD (TR, TR, dominant). The primary outcome was all-cause mortality. Median follow-up was 9.7 months (4.2-12.0).Results
A total of 204 patients were included in the present study: 67 for the RV dominant, 68 for the RV-TR codominant, and 69 for the TR dominant group. The 3 groups presented different baseline characteristics. Survival analysis among the 3 groups showed a trend towards worse prognosis for the RV-dominant group, as compared with the RV-TR codominant and TR dominant groups.Conclusions
The conceptual framework of proportionality is applicable to TR with EROA/RVEDD, defining a higher risk RV-dominant phenotype with a trend towards worse survival after tricuspid transcatheter edge-to-edge repair.
The impact of proportionality to heart valve regurgitation has been widely investigated in mitral regurgitation, helping to better characterize the best candidates for therapies. However, it has never been studied in tricuspid regurgitation (TR). The aim of the present study is to investigate the impact of the proportionality of TR on outcomes.Methods
Patients undergoing tricuspid transcatheter edge-to-edge repair were selected from the TRIVALVE registry (International Multisite Transcatheter Tricuspid Valve Therapies Registry). Patients were divided according to the ratio between effective regurgitant orifice area (EROA) and right ventricular (RV) end diastolic diameter (RVEDD) into tertiles: patients with low EROA/RVEDD (RV, dominant); intermediate EROA/RVEDD (right ventricle and TR, RV-TR, codominant), and high EROA/RVEDD (TR, TR, dominant). The primary outcome was all-cause mortality. Median follow-up was 9.7 months (4.2-12.0).Results
A total of 204 patients were included in the present study: 67 for the RV dominant, 68 for the RV-TR codominant, and 69 for the TR dominant group. The 3 groups presented different baseline characteristics. Survival analysis among the 3 groups showed a trend towards worse prognosis for the RV-dominant group, as compared with the RV-TR codominant and TR dominant groups.Conclusions
The conceptual framework of proportionality is applicable to TR with EROA/RVEDD, defining a higher risk RV-dominant phenotype with a trend towards worse survival after tricuspid transcatheter edge-to-edge repair.
Date Issued
2026-06
Publication Type
Article
Subject(s)
Subjects
heart failure
•
heart valve diseases
•
phenotype
•
prognosis
•
registries
•
survival analysis
•
tricuspid valve insufficiency
Language(s)
en
Author(s)
Russo, Giulio | |
Pedicino, Daniela | |
Adamo, Marianna | |
Alessandrini, Hannes | |
Braun, Daniel | |
Connelly, Kim A | |
Denti, Paolo | |
Estevez-Loureiro, Rodrigo | |
Fam, Neil | |
Hahn, Rebecca T | |
Harr, Claudia | |
Hausleiter, Joerg | |
Kalbacher, Daniel | |
Ho, Edwin | |
Latib, Azeem | |
Lubos, Edith | |
Ludwig, Sebastian | |
Lurz, Philipp | |
Metra, Marco | |
Monivas, Vanessa | |
Nickenig, Georg | |
Pedrazzini, Giovanni | |
Pozzoli, Alberto | |
Rodes-Cabau, Josep | |
Besler, Christian | |
Rommel, Karl-Philipp | |
Schofer, Joachim | |
Scotti, Andrea | |
Lentini, Nicolò | |
Pastorino, Roberta | |
Piayda, Kerstin | |
Sievert, Horst | |
Tang, Gilbert H L | |
Pascual, Isaac | |
Thiele, Holger | |
Schlotter, Florian | |
Sangiorgi, Giuseppe Massimo | |
von Bardeleben, Ralph Stephan | |
Enriquez-Sarano, Maurice | |
Maisano, Francesco | |
Bloechlinger, Stefan | |
Taramasso, Maurizio |
Additional Credits
Journal
Circulation: Cardiovascular Interventions
Publisher
Lippincott, Williams & Wilkins
ISSN
1941-7632
1941-7640
Access(Rights)
restricted