Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells.
Publisher DOI
PubMed ID
27545103
Abstract
The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding environment. Here, silver-containing silica nanorattles (Ag@SiO2) were evaluated for their antimicrobial potential and for their impact on cells of the immune system. We show that Ag@SiO2 nanorattles exhibited a clear antibacterial effect against Escherichia coli as well as Staphylococcus aureus found in post-operative infections. Immunotoxicological analyses showed that the particles were taken up through an active phagocytic process by dendritic cells of the immune system and did not affect their viability nor induce unwanted immunological effects. Silver-containing silica nanorattles thus fulfill several prerequisites for an antibacterial coating on surgical implants.
Date Issued
2017-01
Publication Type
Article
Subjects
Antimicrobial properties
•
Dendritic cells
•
Immunoresponse
•
Nanorattles
•
Silica nanocontainers
•
Silver nanoparticles
Language(s)
en
Author(s)
Priebe, Magdalena | |
Widmer, Jérôme | |
Suhartha Löwa, Nina | |
Abram, Sarah-Luise | |
Mottas, Inès | |
Woischnig, Anne-Kathrin | |
Brunetto, Priscilla S | |
Khanna, Nina | |
Fromm, Katharina M |
Additional Credits
Journal
Nanomedicine: Nanotechnology, Biology and Medicine
Publisher
Elsevier
ISSN
1549-9642
1549-9634
Access(Rights)
restricted