The CD70-CD27 axis in oncology: the new kids on the block.
Publisher DOI
PubMed ID
34991665
Abstract
The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within the tumor and its microenvironment is associated with tumor progression and immunosuppression. This is in contrast to physiological conditions, where tightly controlled expression of CD70 and CD27 plays a role in co-stimulation in immune responses. In hematological malignancies, cancer cells co-express CD70 and CD27 promoting stemness, proliferation and survival of malignancy. In solid tumors, only expression of CD70 is present on the tumor cells which can facilitate immune evasion through CD27 expression in the tumor microenvironment. The discovery of these tumor promoting and immunosuppressive effects of the CD70-CD27 axis has unfolded a novel target in the field of oncology, CD70.In this review, we thoroughly discuss current insights into expression patterns and the role of the CD70-CD27 axis in hematological and solid malignancies, its effect on the tumor microenvironment and (pre)clinical therapeutic strategies.
Date Issued
2022-01-06
Publication Type
Article
Subject(s)
Subjects
CD27 CD70 Combination therapies Hematological malignancies Hematopoiesis Oncology Solid tumors
Language(s)
en
Author(s)
Flieswasser, Tal | |
Van den Eynde, Astrid | |
Van Audenaerde, Jonas | |
De Waele, Jorrit | |
Lardon, Filip | |
de Haard, Hans | |
Smits, Evelien | |
Pauwels, Patrick | |
Jacobs, Julie |
Additional Credits
Journal
Journal of experimental & clinical cancer research
Publisher
BioMed Central
ISSN
1756-9966
Access(Rights)
open.access