Molecular Mechanisms Responsible for Anti-inflammatory and Immunosuppressive Effects of Mesenchymal Stem Cell-Derived Factors.
Publisher DOI
PubMed ID
31175638
Abstract
Mesenchymal stem cells (MSCs) are self-renewable cells capable for multilineage differentiation and immunomodulation. MSCs are able to differentiate into all cell types of mesodermal origin and, due to their plasticity, may generate cells of neuroectodermal or endodermal origin in vitro. In addition to the enormous differentiation potential, MSCs efficiently modulate innate and adaptive immune response and, accordingly, were used in large number of experimental and clinical trials as new therapeutic agents in regenerative medicine. Although MSC-based therapy was efficient in the treatment of many inflammatory and degenerative diseases, unwanted differentiation of engrafted MSCs represents important safety concern. MSC-based beneficial effects are mostly relied on the effects of MSC-derived immunomodulatory, pro-angiogenic, and trophic factors which attenuate detrimental immune response and inflammation, reduce ischemic injuries, and promote tissue repair and regeneration. Accordingly, MSC-conditioned medium (MSC-CM), which contains MSC-derived factors, has the potential to serve as a cell-free, safe therapeutic agent for the treatment of inflammatory diseases. Herein, we summarized current knowledge regarding identification, isolation, ontogeny, and functional characteristics of MSCs and described molecular mechanisms responsible for MSC-CM-mediated anti-inflammatory and immunosuppressive effects in the therapy of inflammatory lung, liver, and kidney diseases and ischemic brain injury.
Date Issued
2019
Publication Type
Book Section
Subject(s)
Subjects
Immunosuppression Inflammatory diseases Mesenchymal stem cells Soluble factors Therapy
Language(s)
en
Author(s)
Harrell, C Randall | |
Jankovic, Marina Gazdic | |
Fellabaum, Crissy | |
Volarevic, Ana | |
Arsenijevic, Aleksandar | |
Volarevic, Vladislav |
Journal
Advances in experimental medicine and biology
Publisher
Springer-Verlag
ISSN
0065-2598
ISBN
978-3-030-19857-2
Access(Rights)
metadata.only