Recurrent Nicolau syndrome associated with subcutaneous glatiramer acetate injection--a case report.
Publisher DOI
PubMed ID
26630967
Abstract
BACKGROUND
Glatiramer acetate is worldwide used as first line treatment in relapsing remitting multiple sclerosis. Local skin reactions associated with glatiramer acetate are common, however, only isolated cases of severe local injection site reactions known as Nicolau Syndrome have been reported so far.
CASE PRESENTATION
We describe the case of a recurrent Nicolau Syndrome occurred during longstanding glatiramer acetate treatment in a woman with multiple sclerosis. The haemorrhagic patch necrotized and was treated locally as a deep second degree burn with excision of dead skin tissue and was healed. Treatment with glatiramer acetate was definitely suspended.
CONCLUSIONS
GA injections can be complicated by isolated or recurrent Nicolau Syndrome, a potentially life-threatening condition of which neurologists should be aware.
Glatiramer acetate is worldwide used as first line treatment in relapsing remitting multiple sclerosis. Local skin reactions associated with glatiramer acetate are common, however, only isolated cases of severe local injection site reactions known as Nicolau Syndrome have been reported so far.
CASE PRESENTATION
We describe the case of a recurrent Nicolau Syndrome occurred during longstanding glatiramer acetate treatment in a woman with multiple sclerosis. The haemorrhagic patch necrotized and was treated locally as a deep second degree burn with excision of dead skin tissue and was healed. Treatment with glatiramer acetate was definitely suspended.
CONCLUSIONS
GA injections can be complicated by isolated or recurrent Nicolau Syndrome, a potentially life-threatening condition of which neurologists should be aware.
Date Issued
2015
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Zecca, Chiara | |
Mainetti, Carlo | |
Gobbi, Claudio |
Additional Credits
Journal
BMC neurology
Publisher
BioMed Central
ISSN
1471-2377
Access(Rights)
open.access