Thrombophilia Testing in Venous Thromboembolism.
Publisher DOI
PubMed ID
40500088
Abstract
Hereditary thrombophilias, comprising factor V Leiden mutation, prothrombin G20210A mutation, protein C, S, and antithrombin deficiency, and acquired antiphospholipid antibody syndrome, predispose venous thromboembolism (VTE) in various mechanisms. Not only the thrombophilia testing and result interpretation requires special laboratory and expertise but also the indications for thrombophilia testing are variable across centers. This is because the role of thrombophilia in VTE management is still under investigation. This narrative review describes the main thrombophilias to be tested, summarizes the indications for thrombophilia testing, and reports the current evidence regarding their role in the duration and choice of anticoagulation in VTE.
Date Issued
2025-07
Publication Type
Article
Subjects
Anticoagulation
•
Antiphospholipid antibody syndrome
•
Thrombophilia testing
•
Venous thromboembolism
Language(s)
en
Additional Credits
Journal
Medical Clinics of North America
Publisher
Elsevier
ISSN
1557-9859
0025-7125
Access(Rights)
restricted