Colorectal cancer: epigenetic alterations and their clinical implications.
Publisher DOI
PubMed ID
28939182
Abstract
Colorectal cancer (CRC) is a heterogeneous disease with distinct molecular and clinical features, which reflects the wide range of prognostic outcomes and treatment responses observed among CRC patients worldwide. Our understanding of the CRC epigenome has been largely developed over the last decade and it is now believed that among thousands of epigenetic alterations present in each tumor, a small subgroup of these may be considered as a CRC driver event. DNA methylation profiles have been the most widely studied in CRC, which includes a subset of patients with distinct molecular and clinical features now categorized as CpG island methylator phenotype (CIMP). Major advances have been made in our capacity to detect epigenetic alterations, providing us with new potential biomarkers for diagnostic, prognostic and therapeutic purposes. This review aims to summarize our current knowledge about epigenetic alterations occurring in CRC, underlying their potential future clinical implications in terms of diagnosis, prognosis and therapeutic strategies for CRC patients.
Date Issued
2017-12
Publication Type
Article
Subject(s)
Subjects
Biomarkers CIMP Colorectal cancer Epigenetic alterations Prognosis Treatment
Language(s)
en
Author(s)
Puccini, Alberto | |
Naseem, Madiha | |
Tokunaga, Ryuma | |
Battaglin, Francesca | |
Cao, Shu | |
Hanna, Diana L | |
McSkane, Michelle | |
Soni, Shivani | |
Zhang, Wu | |
Lenz, Heinz-Josef |
Additional Credits
Journal
Biochimica et biophysica acta
Publisher
Elsevier
ISSN
0006-3002
Access(Rights)
restricted