Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review
Publisher DOI
PubMed ID
38250807
Abstract
Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a “Maestro” role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although a significant amount of work has been conducted on the role of nitric oxide (NO) and carbon monoxide (CO) and their inter-relationship in the field of oncology, research about hydrogen sulfide (H2S) remains in its infancy. Recently, non-coding RNAs (ncRNAs) have been reported to play a dominating role in the regulation of the endogenous machinery system of H2S in several pathological contexts. A growing list of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are leading the way as upstream regulators for H2S biosynthesis in different mammalian cells during the development and progression of human diseases; therefore, their targeting can be of great therapeutic benefit. In the current review, the authors shed the light onto the biosynthetic pathways of H2S and their regulation by miRNAs and lncRNAs in various oncological and non-oncological disorders.
Date Issued
2024-01-18
Publication Type
Article
Subjects
3-MST
•
CBS
•
CSE
•
cancer
•
hydrogen sulfide
•
non-coding RNAs
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non-oncological disorders
Language(s)
en
Author(s)
Youness, Rana A. | |
Habashy, Danira Ashraf | |
Khater, Nour | |
Elsayed, Kareem | |
Dawoud, Alyaa | |
Hakim, Sousanna | |
Nafea, Heba | |
Abdel-Kader, Reham M. | |
Gad, Mohamed Z. |
Additional Credits
Journal
Non-Coding RNA
Publisher
MDPI
ISSN
2311-553X
Access(Rights)
Unknown