NMDA-driven dendritic modulation enables multitask representation learning in hierarchical sensory processing pathways.
Publisher DOI
PubMed ID
37523562
Abstract
While sensory representations in the brain depend on context, it remains unclear how such modulations are implemented at the biophysical level, and how processing layers further in the hierarchy can extract useful features for each possible contextual state. Here, we demonstrate that dendritic N-Methyl-D-Aspartate spikes can, within physiological constraints, implement contextual modulation of feedforward processing. Such neuron-specific modulations exploit prior knowledge, encoded in stable feedforward weights, to achieve transfer learning across contexts. In a network of biophysically realistic neuron models with context-independent feedforward weights, we show that modulatory inputs to dendritic branches can solve linearly nonseparable learning problems with a Hebbian, error-modulated learning rule. We also demonstrate that local prediction of whether representations originate either from different inputs, or from different contextual modulations of the same input, results in representation learning of hierarchical feedforward weights across processing layers that accommodate a multitude of contexts.
Date Issued
2023-08-08
Publication Type
Article
Subject(s)
Subjects
contextual adaptation contrastive learning dendritic computation multitask learning self-supervised learning
Language(s)
en
Author(s)
Wybo, Willem A M | |
Tran, Viet Anh Khoa | |
Illing, Bernd | |
Morrison, Abigail |
Additional Credits
Journal
Proceedings of the National Academy of Sciences of the United States of America - PNAS
Publisher
National Academy of Sciences
ISSN
1091-6490
Access(Rights)
Unknown