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New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.

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cris.virtual.author-orcid0000-0003-2692-6699
cris.virtualsource.author-orcidb7658234-1fce-41a7-8d99-4cdb4e03b6ba
datacite.rightsopen.access
dc.contributor.authorEvangelou, Evangelos
dc.contributor.authorGao, He
dc.contributor.authorChu, Congying
dc.contributor.authorNtritsos, Georgios
dc.contributor.authorBlakeley, Paul
dc.contributor.authorButts, Andrew R
dc.contributor.authorPazoki, Raha
dc.contributor.authorSuzuki, Hideaki
dc.contributor.authorKoskeridis, Fotios
dc.contributor.authorYiorkas, Andrianos M
dc.contributor.authorKaraman, Ibrahim
dc.contributor.authorElliott, Joshua
dc.contributor.authorLuo, Qiang
dc.contributor.authorAeschbacher, Stefanie
dc.contributor.authorBartz, Traci M
dc.contributor.authorBaumeister, Sebastian E
dc.contributor.authorBraund, Peter S
dc.contributor.authorBrown, Michael R
dc.contributor.authorBrody, Jennifer A
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorDimou, Niki
dc.contributor.authorFaul, Jessica D
dc.contributor.authorHomuth, Georg
dc.contributor.authorJackson, Anne U
dc.contributor.authorKentistou, Katherine A
dc.contributor.authorJoshi, Peter K
dc.contributor.authorLemaitre, Rozenn N
dc.contributor.authorLind, Penelope A
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorMangino, Massimo
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorNelson, Christopher P
dc.contributor.authorNolte, Ilja M
dc.contributor.authorPerälä, Mia-Maria
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPorteous, David
dc.contributor.authorRatliff, Scott M
dc.contributor.authorSmith, Jennifer A
dc.contributor.authorStančáková, Alena
dc.contributor.authorTeumer, Alexander
dc.contributor.authorTuominen, Samuli
dc.contributor.authorThériault, Sébastien
dc.contributor.authorVangipurapu, Jagadish
dc.contributor.authorWhitfield, John B
dc.contributor.authorWood, Alexis
dc.contributor.authorYao, Jie
dc.contributor.authorYu, Bing
dc.contributor.authorZhao, Wei
dc.contributor.authorArking, Dan E
dc.contributor.authorAuvinen, Juha
dc.contributor.authorLiu, Chunyu
dc.contributor.authorMännikkö, Minna
dc.contributor.authorRisch, Lorenz
dc.contributor.authorRotter, Jerome I
dc.contributor.authorSnieder, Harold
dc.contributor.authorVeijola, Juha
dc.contributor.authorBlakemore, Alexandra I
dc.contributor.authorBoehnke, Michael
dc.contributor.authorCampbell, Harry
dc.contributor.authorConen, David
dc.contributor.authorEriksson, Johan G
dc.contributor.authorGrabe, Hans J
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorHartman, Catharina A
dc.contributor.authorHayward, Caroline
dc.contributor.authorHeath, Andrew C
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorKähönen, Mika
dc.contributor.authorKardia, Sharon L R
dc.contributor.authorKühne, Michael
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorLaakso, Markku
dc.contributor.authorLahti, Jari
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorMohlke, Karen L
dc.contributor.authorMorrison, Alanna C
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorOldehinkel, Albertine J
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorRudan, Igor
dc.contributor.authorSamani, Nilesh J
dc.contributor.authorScott, Laura J
dc.contributor.authorSpector, Tim D
dc.contributor.authorVerweij, Niek
dc.contributor.authorWeir, David R
dc.contributor.authorWilson, James F
dc.contributor.authorLevy, Daniel
dc.contributor.authorTzoulaki, Ioanna
dc.contributor.authorBell, Jimmy D
dc.contributor.authorMatthews, Paul M
dc.contributor.authorRothenfluh, Adrian
dc.contributor.authorDesrivières, Sylvane
dc.contributor.authorSchumann, Gunter
dc.contributor.authorElliott, Paul
dc.date.accessioned2024-10-11T17:39:17Z
dc.date.available2024-10-11T17:39:17Z
dc.date.issued2019-09
dc.description.abstractExcessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d-1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
dc.description.numberOfPages12
dc.description.sponsorshipUniversitätsinstitut für Klinische Chemie (UKC)
dc.identifier.doi10.48350/174991
dc.identifier.pmid31358974
dc.identifier.publisherDOI10.1038/s41562-019-0653-z
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/89059
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofNature human behaviour
dc.relation.issn2397-3374
dc.relation.organizationInstitute of Clinical Chemistry
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleNew alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
dc.typearticle
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oaire.citation.endPage961
oaire.citation.issue9
oaire.citation.startPage950
oaire.citation.volume3
oairecerif.author.affiliationUniversitätsinstitut für Klinische Chemie (UKC)
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unibe.date.licenseChanged2022-11-22 15:26:31
unibe.description.ispublishedpub
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